Results 41 to 50 of about 39,670 (263)

Co-Crystallization Adducts of Carvedilol with Carboxylic Acids: Design and Characterization

Proceedings
Carvedilol (CARV) belongs to the group of non-selective beta and alpha-1 adrenergic receptor antagonists and is indicated for hypertension and chronic heart failure [...]
Ema-Teodora Nițu, Luciana Buliga, Ioana Mitrofan, Amalia Ridichie, Cornelia Muntean, Ionuţ Ledeţi, Adriana Ledeți, Laura Sbârcea   +7 more
doaj   +1 more source

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Anglin IE, Boris Schlenker, Chang L, Chon JK, Christ GJ, Christian G. Stief, Christian Gratzke, Erdogru T, Frank Strittmatter, Glassman DT, Golomb E, Johanna Göttinger, Kanagawa K, Karl-Erik Andersson, Kyprianou N, Kyprianou N, Kyprianou N, Lucia MS, Luthin GR, Marinese D, Maroni PD, Martin Hennenberg, McCubrey JA, McVary KT, Michel MC, Oliver Reich, Petter Hedlund, Ricarda M. Bauer, Roehrborn CG, Roehrborn CG, Royuela M, Royuela M, Schilit S, Schwinn DA, Shimada K, Srinivasan D, Turkeri LN, Xiao L, Zhang H, Zhang Z   +39 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis

International Brazilian Journal of Urology, 2015
Introduction: Urinary lithiasis is the main urologic cause of emergency treatment in adult patient. In the past years, the incidence in children population has increased.
F.P. Glina, P.M.V. Castro, G.G.R. Monteiro, G.C. Del Guerra, S. Glina, M. Mazzurana, W.M. Bernardo   +6 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Late expression of alpha 2-adrenergic-mediated antilipolysis during differentiation of hamster preadipocytes.

Journal of Lipid Research, 1991
In order to study the ontogenesis of the beta- and alpha 2-adrenergic control of lipolysis during the adipose conversion process, a model based on preadipocytes isolated from the stromal-vascular fraction of hamster adipose tissue was developed.
JS Saulnier-Blache, M Dauzats, D Daviaud, D Gaillard, G Ailhaud, R Négrel, M Lafontan   +6 more
doaj   +1 more source

Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area [PDF]

, 2014
The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA)
Baker, David A., Gasser, Paul J, Gerndt, Clayton H., Mantsch, John R., Vranjkovic, Oliver   +4 more
core   +2 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Effects of prostatic inflammation on LUTS and alpha blocker treatment outcomes

International Brazilian Journal of Urology, 2014
Purpose To evaluate the association between prostatic inflammation and lower urinary tract symptoms (LUTS), and to identify the effects of prostatic inflammation on the treatment with an alpha blocker.
Ha Na Lee, Tae-Hyoung Kim, Sun-Ju Lee, Won Yeol Cho, Bong Suk Shim   +4 more
doaj   +1 more source

Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing

BMC Geriatrics, 2022
Background Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant ...
Felix Mansbart, Gerda Kienberger, Andreas Sönnichsen, Eva Mann   +3 more
doaj   +1 more source