Results 41 to 50 of about 26,766 (264)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Effect of a Reduced-Calorie Diet on alpha-2 Adrenergic Receptor Responsiveness in Abdominal Adipose Tissue in Obese Men During Exercise [PDF]
, 2008 There is at present an imperfect understanding of the effect of diet on availability of inhibitory receptors in fat cells during exercise among obese men. *Objective:* The purpose of this study was to determine whether diet results in
Roy R. Estrada +3 more
core +1 more source
Quantitative structure-activity relationships of alpha(1) adrenergic antagonists [PDF]
, 2004 A quantitative structure-activity relationship study with respect to selectivity for alpha(1) adrenoreceptor subtypes (alpha(1a), alpha(1b) and alpha(1d)) of a wide series of structurally heterogeneous alpha(1) adrenoreceptor antagonists has been ...
Zupan, Janja +5 more
core +1 more source
International Brazilian Journal of Urology, 2015 Introduction: Urinary lithiasis is the main urologic cause of emergency treatment in adult patient. In the past years, the incidence in children population has increased.
F.P. Glina +6 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Journal of Lipid Research, 1991 In order to study the ontogenesis of the beta- and alpha 2-adrenergic control of lipolysis during the adipose conversion process, a model based on preadipocytes isolated from the stromal-vascular fraction of hamster adipose tissue was developed.
JS Saulnier-Blache +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Effects of prostatic inflammation on LUTS and alpha blocker treatment outcomes
International Brazilian Journal of Urology, 2014 Purpose To evaluate the association between prostatic inflammation and lower urinary tract symptoms (LUTS), and to identify the effects of prostatic inflammation on the treatment with an alpha blocker.
Ha Na Lee +4 more
doaj +1 more source
BMC Geriatrics, 2022 Background Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant ...
Felix Mansbart +3 more
doaj +1 more source
Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function
Advanced Healthcare Materials, EarlyView.Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo +8 more
wiley +1 more source