Results 141 to 150 of about 94,283,903 (258)

Circular RNAs in Drug‐Induced Cardiotoxicity: Roles, Mechanisms, and Therapeutic Potential

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Circular RNAs have emerged as novel regulators and potential biomarkers in drug‐induced cardiotoxicity. This review summarizes the biogenesis, functional roles, and translational potential of circRNAs in cardiotoxicity assessment and drug safety evaluation.
KeXin Leng, Zixuan Yang, Lei Shi, Zhimin Sun, Mengyun Gu, Naping Tang   +5 more
wiley   +1 more source

β2-adrenergic receptor stimulation drives differentiation of human adipose-derived mesenchymal stem cells into beige adipocytes. [PDF]

Adipocyte
Maekawa K, Yokoyama F, Tsutsumi R, Tateishi A, Maeda A, Tateishi N.   +5 more
europepmc   +1 more source

How Can We Personalize the Delivery of Onabotulinumtoxin‐A for Patients With Neurogenic Lower Urinary Tract Dysfunction?

Neurourology and Urodynamics, Volume 45, Issue 8, Page 1500-1506, November 2026.
ABSTRACT Background & Aims Neurogenic lower urinary tract dysfunction (NLUTD) can produce bothersome urinary symptoms, impact quality of life, and in some cases, lead to deterioration of upper urinary tract function. Intradetrusor injection of onabotulinumtoxin‐A (BoNT‐A) is approved for NLUTD in patients who have an inadequate response to or ...
Shirley L. Wang, William I. Jaffe, Ariana L. Smith   +2 more
wiley   +1 more source

Sex- and Age-Specific Trends in Prescriptions of Beta-3 Agonists and Anticholinergics in Japan: A Nationwide Prescription Database Study. [PDF]

Low Urin Tract Symptoms
Yokoyama M, Onuki A, Koshi K, Tsukahara S, Negami H, Shiba K, Kato Y, Kojima A, Kato D, Amemiya T, Nenohi T, Urushibara M, Fujiwara M, Asano T, Kano H, Ishizaka K.   +15 more
europepmc   +1 more source

Continuous Imaging of the Cardiac Cycle Metabolism With Hyperpolarized [1‐13C]Pyruvate

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
We present a continuous hyperpolarized 13C MRI framework for phase‐resolved imaging of myocardial metabolism throughout the entire cardiac cycle. By combining spectral‐spatial bicarbonate excitation with frequency‐shifted reconstruction of residual pyruvate signal, both metabolites are obtained from a single acquisition.
Mohsen Redda, Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Uffe Kjærgaard, Rolf F. Schulte, Christoffer Laustsen   +5 more
wiley   +1 more source

Guanfacine as a potential preventive therapy for chronic migraine: a mechanistic hypothesis. [PDF]

Front Neurol
Kesayan T, Patel K.
europepmc   +1 more source

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT The target‐engagement predictor, implemented within the InSilicoTrials cloud‐based, AI‐powered platform for model‐informed drug discovery and development, enables early exploration of time‐dependent pharmacological responses. Predictions can be generated using inputs ranging from molecular structure to in vitro, animal, and clinical data ...
Niccolò Totis, Fianne Sips, Simona Catozzi, Marc‐Antonio Bisotti, Pauline Bambury, Sofia Stathopoulos, Vincenzo Carbone, Luca Emili, Mario Torchia, Valentina Belgiovine, Fulvio Ciriaco, Orazio Nicolotti, Urban Fagerholm, Candice N. Baker, J. Matthew Mahoney, Daniel Röshammar, on behalf of the CARDIOVERSE Project   +16 more
wiley   +1 more source

Prescription Trends in the Management of Lower Urinary Tract Symptoms in Men: An Online Survey of Indian Urologists. [PDF]

Cureus
Patwardhan P, Palkar S, Sharma R, Kamble S, Dhurandhar S.   +4 more
europepmc   +1 more source

Cutaneous‐only hypersensitivity reaction presumed due to intravenous administration of atracurium in a dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Summary There are limited case reports of hypersensitivity reactions to neuromuscular blocking agents (NMBAs) in veterinary species, and none describe cutaneous‐only signs. This case report describes a Grade 1 cutaneous‐only hypersensitivity reaction to atracurium in a 7‐year‐old dog undergoing general anaesthesia for cataract surgery with bilateral ...
Kar Yee Phoon, Rob Ward
wiley   +1 more source

Sartans and Bisartans: Expanding Therapeutic Horizons Through Broad Receptor Interactions and Repurposing Potential. [PDF]

Int J Mol Sci
Petsas E, Apostolopoulos V, Kiouri DP, Kelaidonis K, Ridgway H, Moore GJ, Mavromoustakos T, Gadanec LK, Matsoukas JM, Chasapis CT.   +9 more
europepmc   +1 more source