Results 111 to 120 of about 945,289 (264)

Frequency of coprescription and potential risk of bronchospasm in Colombian patients users of topical antiglaucomatous betablockers and bronchodilators

Vitae, 2014
Background: Cardiovascular and respiratory effects of adrenergic agonists used in diseases like chronic obstructive pulmonary disease (COPD), and β-blockers used in glaucoma generate competitive antagonism on the same adrenergic receptor when used ...
Jorge Enrique Machado-Alba, Valentina Hoyos-Soto   +1 more
doaj  

Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH)

npj Metabolic Health and Disease
MASH is a leading cause of liver transplantation. Here, we investigated formoterol, a long-acting β2 adrenergic receptor agonist (LABA), in MASH. Mice treated with a high-fat diet (HFD) for sixteen weeks developed liver steatosis and were treated with ...
Brennan S. Winkler, Kristina M. Stayer, Abhinav K. Rao, Ehtesham Arif, Tsultrim T. Mendenhall, Kristy L. Thomas, Kylie R. Driggers, Xiaofeng Zuo, Wayne Fitzgibbon, Peifeng Deng, Yanhui Su, Yujing Dang, Marie Gerges, Daniel Kagan, Vishwajeeth Pasham, Bethany Wolf, Don C. Rockey, Jessica H. Hartman, Joshua H. Lipschutz   +18 more
doaj   +1 more source

A pharmacodynamic study on clenbuterol-induced toxicity: beta(1)- and beta(2)-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model

, 2007
Beta(2)-receptor adrenergic agonists as clenbuterol and analogues are illegally used as growth promoters in cattle, in Europe, as well as in other countries. We investigated whether heart rate increase induced by clenbuterol could depend upon stimulation
BRAMBILLA G, FIORI M, LOIZZO A., DANIELE C, LOIZZO S, DI SOTTO, ANTONELLA, BATTINELLI L, MAZZANTI, Gabriela   +7 more
core   +1 more source

Angiotensin II Attenuates the Bioactivities of Human Endothelial Progenitor Cells via Downregulation of β2-Adrenergic Receptor

Stem Cells International, 2018
Cross talks between the renin-angiotensin system (RAS), sympathetic nervous system, and vascular homeostasis are tightly coordinated in hypertension.
Seon Jin Lee, Da Yeon Kim, Jisoo Yun, Sung Hyun Choi, Seok Yun Jung, Songhwa Kang, Ji Hye Park, Yeon Ju Kim, Jong Seong Ha, Seung Taek Ji, Woong Bi Jang, Dong Hyung Lee, Dongjun Lee, Sang-Mo Kwon   +13 more
doaj   +1 more source

Blood pressure increases and other safety and medication compliance in overactive bladder patients treated with Selebeta® PR tablets: A noninterventional, multicenter, retrospective observational study [PDF]

Investigative and Clinical Urology
Purpose: This study aimed to evaluate the safety, including blood pressure changes, and medication compliance associated with a generic prolonged-release formulation of mirabegron (Selebeta® PR Tab.
Jong Hoon Lee, Aram Kim, Ji Sung Shim, Kwang Jin Ko   +3 more
doaj   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Cancer Science, EarlyView.
Psychological stress promotes hepatocellular carcinoma progression through coordinated regulation of macrophages and neutrophils. Noradrenaline activates ADRB2 signaling in intratumoral macrophages, leading to CXCL2 production and neutrophil recruitment.
Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi   +13 more
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets

International Journal of Endocrinology, 2018
Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present ...
Silvano Piovan, Audrei Pavanello, Giuliana Maria Ledesma Peixoto, Camila Cristina Ianoni Matiusso, Ana Maria Praxedes de Moraes, Isabela Peixoto Martins, Ananda Malta, Kesia Palma-Rigo, Claudinéia Conationi da Silva Franco, Paula Gimenez Milani, Antonio Sérgio Dacome, Silvio Claudio da Costa, Paulo Cezar de Freitas Mathias, Cecília Edna Mareze-Costa   +13 more
doaj   +1 more source