Results 131 to 140 of about 25,120 (238)

Efficacy and safety of different vasopressor infusions on feto‐maternal outcomes in normotensive patients undergoing caesarean delivery: a systematic review and network meta‐analysis of randomised controlled trials

open access: yesAnaesthesia, Volume 81, Issue 7, Page 995-1007, July 2026.
Summary Introduction Phenylephrine infusion is widely endorsed by guidelines as the preferred prophylactic drug for spinal hypotension in patients undergoing caesarean delivery; however, clinical practice continues to show marked variability in the selection of vasopressor drugs.
Narinder Pal Singh   +4 more
wiley   +1 more source

Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling. [PDF]

open access: yesJ Mol Cell Cardiol Plus
Li W   +8 more
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim   +5 more
wiley   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

open access: yesObesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso   +7 more
wiley   +1 more source

The Early Ophthalmic Effects of Vatinoxan in Healthy Detomidine‐Sedated Horses

open access: yesVeterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective To evaluate the short‐term ophthalmic effects of vatinoxan, a peripherally selective alpha2‐adrenoceptor antagonist, in detomidine‐sedated horses. Animals Studied Seven healthy horses without ophthalmic disease in a randomized, masked, two‐period crossover study design, with a ≥ 7‐day rest period.
Minna Pauliina Mustikka   +5 more
wiley   +1 more source

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