Summary Introduction Phenylephrine infusion is widely endorsed by guidelines as the preferred prophylactic drug for spinal hypotension in patients undergoing caesarean delivery; however, clinical practice continues to show marked variability in the selection of vasopressor drugs.
Narinder Pal Singh +4 more
wiley +1 more source
Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling. [PDF]
Li W +8 more
europepmc +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Effect of the gut microbiota metabolite phenylacetylglycine on cardiac Ca<sup>2+</sup> signaling. [PDF]
Bovo E, Zima AV.
europepmc +1 more source
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim +5 more
wiley +1 more source
Heterogeneity of estrogen and β-adrenergic receptors in female human coronary artery endothelial cells. [PDF]
Elsaid B +4 more
europepmc +1 more source
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso +7 more
wiley +1 more source
Β3-Adrenergic Receptors and Prematurity-Related Diseases: A Systematic Review. [PDF]
Fazi C, Dani C.
europepmc +1 more source
The Early Ophthalmic Effects of Vatinoxan in Healthy Detomidine‐Sedated Horses
ABSTRACT Objective To evaluate the short‐term ophthalmic effects of vatinoxan, a peripherally selective alpha2‐adrenoceptor antagonist, in detomidine‐sedated horses. Animals Studied Seven healthy horses without ophthalmic disease in a randomized, masked, two‐period crossover study design, with a ≥ 7‐day rest period.
Minna Pauliina Mustikka +5 more
wiley +1 more source
Dopaminergic modulation of pancreatic beta-cell insulin secretion and implications for antipsychotic-induced glucose dysregulation: a systematic review and meta-analysis. [PDF]
Al-Hasani W +5 more
europepmc +1 more source

