miR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Bernardo J. Krause +12 more
wiley +1 more source
Fibre Type-Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta<sub>2</sub>-Adrenergic Agonist. [PDF]
Jessen S +9 more
europepmc +1 more source
Reproxalap ‐ A Novel Treatment Option for Allergic Conjunctivitis – A Comprehensive Narrative Review
ABSTRACT Background and Aims Allergic conjunctivitis is a prevalent, immune‐mediated hypersensitivity disorder of the ocular surface affecting 10%–20% of the global population. Current therapeutic options, while effective to some extent, are often limited by side effects and inconsistent efficacy.
Sanila Mughal +7 more
wiley +1 more source
Comparative anatomy and metabolic profiles of brown and white adipose tissue in humans. [PDF]
Villarreal J, Baranova A.
europepmc +1 more source
ABSTRACT Background and Aims There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS.
Leili Hafizi +7 more
wiley +1 more source
Clinical Outcomes Associated With Long-Acting Beta Agonist Escalation in Preschool Children With Severe Asthma: A Retrospective Hospital Based Clinic Cohort Study. [PDF]
Eizner AM +3 more
europepmc +1 more source
Ephedrine‐Triggered Torsades de Pointes in Two Patients Following Desflurane‐Induced QT Prolongation
Desflurane‐induced QT prolongation followed by ephedrine‐triggered premature ventricular contractions led to torsades de pointes/ventricular fibrillation in two patients. These cases demonstrate sequential electrocardiographic progression and highlight the importance of careful vasopressor selection during general anesthesia.
Shinichi Harada +4 more
wiley +1 more source
Iron Matters: Comparative Impact of Beta-Adrenergic Stimulation and Iron Chelation on Cardiac Iron Metabolism and Mitochondrial Function. [PDF]
Francesch-Manzano J +11 more
europepmc +1 more source
Innovative Drug Delivery Systems for the Treatment of Glaucoma
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu +9 more
wiley +1 more source
Prostaglandin analog therapy challenges and innovation in glaucoma therapeutics. [PDF]
Nath M +4 more
europepmc +1 more source

