Results 161 to 170 of about 116,135 (274)

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

Performance-Enhancing Effects of Inhaled Medications: Implications for Heart, Muscle Function, and Doping Detection in Athletes. [PDF]

J Funct Morphol Kinesiol
Cricco R, Segreti A, Stirpe E, Ferro A, Ciancio M, Cipriani F, Fossati C, Ussia GP, Pigozzi F, Grigioni F.   +9 more
europepmc   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

An Explorative Approach to Examining the Role of Ischemia and Inflammation on the Function of Autoantibodies Against G Protein-Coupled Receptors and Their Corresponding Agonists. [PDF]

Int J Mol Sci
Wallukat G, Lakatos P, Steinhorst K, Flecks M, Hohberger B.   +4 more
europepmc   +1 more source

Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells.

Biochimica et Biophysica Acta, 2003
M. Arai, Tsuneyasu Nagasawa, Y. Koshihara, Seizo Yamamoto, A. Togari   +4 more
semanticscholar   +1 more source

Targeting Elastin‐Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease

MedComm, Volume 7, Issue 8, August 2026.
In COPD, extracellular matrix and elastin degradation increase elastin‐derived peptides (EDPs), which are associated with TLR4/NF‐κB activation, DKK1 upregulation, reduced β‐catenin signaling, and impaired AT2‐to‐AT1 differentiation. Neutralization of EDPs by TB partially restores β‐catenin‐associated alveolar epithelial differentiation and attenuates ...
Huijuan Zhu, Yiling Zhao, Yingchao Qin, Wenfeng Huang, Jiarui Weng, Zihan Liu, Jiahong Kuang, Zibei Feng, Zhilian Ye, Peiji Zheng, Xiaolan Guo, Fei Cui, Bingjie Chen, Pixin Ran, Jianwei Dai   +14 more
wiley   +1 more source

Fibre Type-Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta₂-Adrenergic Agonist. [PDF]

J Cachexia Sarcopenia Muscle
Jessen S, Di Credico A, Moreno-Justicia R, Moesgaard L, Lemminger A, Stocks B, Di Baldassarre A, Bangsbo J, Deshmukh AS, Hostrup M.   +9 more
europepmc   +1 more source

Trends and Racial/Ethnic Disparities in Pharmacologic and Surgical Management of Treated Female Patients With Urinary Incontinence

Neurourology and Urodynamics, Volume 45, Issue 6, Page 1062-1070, August 2026.
ABSTRACT Background The current literature summarizes the trends in the surgical management of stress urinary incontinence (SUI) and not the general trends of management for all UI types in the US. Additionally, recent evidence on racial and ethnic disparities in UI related surgical utilization is limited. Objective To describe the currently prescribed
Rawan O. Almadfaa, Patricia R. Wigle, Alex C. Lin, Angelica Hardee, Jeff J. Guo, Ana L. Hincapie   +5 more
wiley   +1 more source

ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice

Obesity, Volume 34, Issue 8, Page 1635-1646, August 2026.
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen, Tenagne D. Challa, Carlos Villaroel‐Vicente, Marcela Borsigova, Pim P. van Krieken, Christian Wolfrum, Matthias Blüher, Stephan Wueest, Daniel Konrad   +8 more
wiley   +1 more source

Clinical Outcomes Associated With Long-Acting Beta Agonist Escalation in Preschool Children With Severe Asthma: A Retrospective Hospital Based Clinic Cohort Study. [PDF]

Pediatr Pulmonol
Eizner AM, Mandelberg A, Ovadia A, Domany KA.   +3 more
europepmc   +1 more source