Results 171 to 180 of about 25,120 (238)

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate. [PDF]

Low Urin Tract Symptoms
Filzmayer M, Traumann MI, Humke C, Müller MJ, Mandel PC, Kluth LA, Becker A, Chun FK, Kosiba M.   +8 more
europepmc   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands. [PDF]

ACS Chem Biol
Putansu A, Solowiej I, Rivett-Trznadel H, Lakkanasirorat B, Moran L, Kroning KE, Liu J, Li X, Li P, Wang W.   +9 more
europepmc   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Therapeutic Potential of the β3-Adrenergic Receptor and Its Ligands in Cardiovascular Diseases. [PDF]

Int J Mol Sci
Kempiński M, Jańczak P, Porębska A, Zawadzka PS, Jastrzębska P, Granat MM, Wojciechowska M.   +6 more
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status. [PDF]

Endocrinol Metab (Seoul)
Lee J, Kwak JY, Lee HY, Moon JS, Jang HJ, Nga HT, Nguyen TL, Abdillah AM, Kim J, Kim S, Yang YR, Lee JE, Yi HS.   +12 more
europepmc   +1 more source

Mirabegron exhibits antibacterial and Immunomodulatory activities demonstrated by in vitro and in vivo studies. [PDF]

Sci Rep
Ahmed EA, Abd-Eldayem AM.
europepmc   +1 more source