Results 171 to 180 of about 116,135 (274)

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Prostaglandin analog therapy challenges and innovation in glaucoma therapeutics. [PDF]

Indian J Ophthalmol
Nath M, Alam K, Halder N, Dada T, Thirumurthy V.   +4 more
europepmc   +1 more source

Limited Evidence of Noradrenaline Use and Effectiveness in Preterm Neonates: A Systematic Review

Acta Paediatrica, Volume 115, Issue 8, Page 1611-1619, August 2026.
ABSTRACT Aim The study aimed to analyse the effects and associated outcomes of noradrenaline in treating hypotension in preterm neonates. Methods We searched PubMed, Web of Science, and Scopus to August 2025 for randomised and observational studies on noradrenaline use in preterm neonates.
A. Vänskä, U. Sankilampi, I. Kuitunen
wiley   +1 more source

Iron Matters: Comparative Impact of Beta-Adrenergic Stimulation and Iron Chelation on Cardiac Iron Metabolism and Mitochondrial Function. [PDF]

Biomolecules
Francesch-Manzano J, Tajes M, Ramos-Polo R, Enjuanes C, Ras-Jiménez MDM, Cosa AE, Marinova K, Enrich-Soria C, Moliner P, Lorenzo-Esteller L, José-Bazán N, Comín-Colet J.   +11 more
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High-Dose Salbutamol During Resistance Training: A Randomized Controlled Trial. [PDF]

Scand J Med Sci Sports
Hostrup M, Jessen S, Tischer SG, Kalsen A, Hadad R, Bonde PL, Kreiberg M, Gad AS, Sajadieh A, Backer V, Bangsbo J, Rasmusen H.   +11 more
europepmc   +1 more source

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?

General Psychiatry, Volume 39, Issue 4, August 2026.
Peng Wei, Pianpian Zhao, Zenghui Gu, Mengyuan Yang, David Karasik, Ching‐Lung Cheung, Houfeng Zheng   +6 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Characterization of Usage Patterns of Drugs Suspected to Cause Adverse Drug Reactions in Older Hospitalized Patients

Geriatrics &Gerontology International, Volume 26, Issue 8, August 2026.
ABSTRACT Aim This study aimed to characterize the usage patterns of drugs suspected to cause adverse drug reactions (ADRs) in older hospitalized patients. Methods Medical records of older adults admitted to the Department of Geriatrics and Hypertension at Osaka University Hospital from September 2014 to August 2021 were reviewed.
Mizuki Katsuhisa, Shota Hamada, Chie Hamaie, Yuko Takeshita, Kasumi Ikuta, Yuichiro Saizen, Eriko Koujiya, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya   +9 more
wiley   +1 more source

COPD-Asthma-Heart Failure Overlap: Optimizing Bronchodilators and ICS in a High-Risk Triad. [PDF]

J Asthma Allergy
Fu X, Han G.
europepmc   +1 more source