Results 181 to 190 of about 945,289 (264)

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10459-10474, November 2026.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Impact of combined Hydrus Microstent implantation and cataract surgery on diurnal intraocular pressure range: a longitudinal, retrospective study. [PDF]

BMC Ophthalmol
Thelen P, Reinhard T, Helmers G, Böhringer D, Lübke J, Keye P.   +5 more
europepmc   +1 more source

Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Long summer‐like photoperiod reduces SK channel function in dorsal raphe serotonin neurons. SK channel blockade with apamin increases firing rate in slices from short‐photoperiod mice, mimicking the elevated firing seen in long‐photoperiod mice. Whole‐cell recordings show that apamin‐sensitive tail currents are smaller in long‐photoperiod neurons ...
Manuel A. Giannoni‐Guzmán, José C. Zepeda, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Brad A. Grueter, Douglas G. McMahon   +6 more
wiley   +1 more source

β₂-agonist toxicity in pregnancy causing troponin elevation and fetal distress. [PDF]

BMJ Case Rep
Stobie W, Joseph F.
europepmc   +1 more source

Subclinical Cerebral Lesions in Migraine: A Proof‐of‐Concept Study on Platelet Aggregation

European Journal of Neurology, Volume 33, Issue 11, November 2026.
We assessed platelet aggregation in patients with migraine (n = 34) with or without cerebral white‐matter lesions (WMLs) versus matched controls (n = 34), with WMLs volume quantified by MRI (mm3). Aggregation to ADP, collagen, epinephrine, and arachidonic acid was measured; epinephrine‐induced aggregation at 1.25–2.5 μM was overall lower in migraine ...
Ilaria Maestrini, Mariaignazia Curreli, Marta Puma, Costanza Giannì, Eleonora Schiera, Giada Giuliani, Massimiliano Toscano, Marta Altieri, Patrizia Pantano, Fabio Pulcinelli, Vittorio Di Piero   +10 more
wiley   +1 more source

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives. [PDF]

Clin Exp Med
Zhao J, Han Y, Li Y, Li Y, Sun Y, Bai Y, Chen J, Han C, Yan Y, Zhou C, Liu C.   +10 more
europepmc   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Sartans and Bisartans: Expanding Therapeutic Horizons Through Broad Receptor Interactions and Repurposing Potential. [PDF]

Int J Mol Sci
Petsas E, Apostolopoulos V, Kiouri DP, Kelaidonis K, Ridgway H, Moore GJ, Mavromoustakos T, Gadanec LK, Matsoukas JM, Chasapis CT.   +9 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source