Results 181 to 190 of about 51,117 (269)

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects. Existing predictors are substrate‐agnostic and cannot capture how a single amino acid change differentially affects transport across
Yoomi Park, Yitian Zhou, Ming Xiao, Anne T. Nies, Volker M. Lauschke   +4 more
wiley   +1 more source

Performance-Enhancing Effects of Inhaled Medications: Implications for Heart, Muscle Function, and Doping Detection in Athletes. [PDF]

J Funct Morphol Kinesiol
Cricco R, Segreti A, Stirpe E, Ferro A, Ciancio M, Cipriani F, Fossati C, Ussia GP, Pigozzi F, Grigioni F.   +9 more
europepmc   +1 more source

Adipose Triglyceride Lipase and Gpr40 Contribute to the Anti‐Contractile Effect of Perivascular Adipose Tissue

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Objective Perivascular adipose tissue (PVAT) surrounds most peripheral blood vessels and exerts an anti‐contractile influence through paracrine mediators. Although numerous vasoactive factors have been identified, the mechanisms linking adipocyte metabolism to PVAT‐dependent modulation of vascular tone remain poorly defined. Because adipocytes
Miranda Hyatt, Rinaldo Rodrigues Dos Passos, Fenix A. Araujo, Emily W. Wilson, Emily W. Waigi, Tiago J. Costa, Darízy F. Silva, R. Clinton Webb, Camilla F. Wenceslau, Cameron G. McCarthy   +9 more
wiley   +1 more source

Prostaglandin analog therapy challenges and innovation in glaucoma therapeutics. [PDF]

Indian J Ophthalmol
Nath M, Alam K, Halder N, Dada T, Thirumurthy V.   +4 more
europepmc   +1 more source

Adipocyte‐specific FFA2 deletion leads to increased adipose inflammation and is associated with altered intestinal lipid handling in mice

Physiological Reports, Volume 14, Issue 9, May 2026.
Abstract Obesity and related metabolic disorders are often characterized by chronic adipose tissue inflammation, driving systemic insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2) has emerged as a potential modulator of adipocyte function, inflammation, and metabolism.
Chioma Nnyamah, James Boyett, Barton Wicksteed, Nupur Pandya, Kai Xu, Irene Corona‐Avila, Nadia Sweis, Marissa St. George, Laura J. Den Hartigh, Abeer M. Mahmoud, Yuwei Jiang, Jose Cordoba‐Chacon, Medha Priyadarshini, Brian T. Layden   +13 more
wiley   +1 more source

COPD-Asthma-Heart Failure Overlap: Optimizing Bronchodilators and ICS in a High-Risk Triad. [PDF]

J Asthma Allergy
Fu X, Han G.
europepmc   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model. [PDF]

Pulm Circ
Mendes-Ferreira P, Tielemans B, Wagenaar A, Bouzin C, Adão R, Pokreisz P, De Mulder D, Leite-Moreira A, Brás-Silva C, Balligand JL, Dessy C, Delcroix M, Quarck R, Belge C.   +13 more
europepmc   +1 more source

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot, Iván Lavandera, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

Thermogenesis in Adipose Tissue: Adrenergic and Non-Adrenergic Pathways. [PDF]

Cells
Hossain MA, Poojari A, Rabiee A.
europepmc   +1 more source