Results 121 to 130 of about 25,120 (238)

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Linezolid‐induced lactic acidosis in critically ill patients: A multicentre study of incidence, severity and predictors

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2239-2249, July 2026.
Abstract Introduction Linezolid, a synthetic oxazolidinone for resistant gram‐positive infections, is generally associated with mild adverse effects such as gastrointestinal disturbances, but more serious reactions like lactic acidosis (LA) have also been reported.
Lina Naseralallah, Bodoor Aboujabal, Zahra Noureddine, Khaled Aboujabal, Somaya Koraysh   +4 more
wiley   +1 more source

Navigating the challenges of overactive bladder management in women. [PDF]

World J Urol
Braga A, Goldman HB, Padoa A, Serati M.
europepmc   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 94-108, July 2026.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice. [PDF]

Prog Neurobiol
Antonucci S, Caron G, Dikwella N, Krishnamurthy SS, Harster A, Wasicki B, Zarrin H, Tahanis A, Heuvel FO, Danner SM, Ludolph AC, Grycz K, Bączyk M, Zytnicki D, Roselli F.   +14 more
europepmc   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Systemic α₂-agonist use and lower hazard of glaucoma compared with β-blockers: a cohort study. [PDF]

BMJ Open Ophthalmol
Abboud I, Khudari AZ, Abdelaal A, Almobayed A, Al'Aref SJ, Myers JS, Lee RK, Elhusseiny AM.   +7 more
europepmc   +1 more source

Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 70-78, July 2026.
Abstract Preterm birth occurs in approximately 10% of all pregnancies, and is not only the leading cause of neonatal mortality but also a major contributor to short‐ and long‐term morbidities due to immaturity. Preterm birth has also been linked to an increased risk of maternal cardiovascular and cerebrovascular diseases, making it a critical concern ...
Hikaru Imatake, Yoshitsugu Chigusa, Haruta Mogami, Satoshi Morita, Masaki Mandai   +4 more
wiley   +1 more source

Mirabegron administration for the prevention of ureteral injuries during ureteral access sheath insertion. [PDF]

World J Urol
Ermiş O, Sabuncu K, Kaçtan Ç, Karakuş B, Sürmeli B, Boz MY, Horuz R.   +6 more
europepmc   +1 more source

The Orexin System Modulates Stress‐Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence

Addiction Biology, Volume 31, Issue 7, July 2026.
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He, Aqian Hu, Tianshu Zhao, Li Deng, Huilin Wu, Xiaojun Xiang   +5 more
wiley   +1 more source