Results 121 to 130 of about 53,199 (316)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
core   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Frequency of coprescription and potential risk of bronchospasm in Colombian patients users of topical antiglaucomatous betablockers and bronchodilators

Vitae, 2014
Background: Cardiovascular and respiratory effects of adrenergic agonists used in diseases like chronic obstructive pulmonary disease (COPD), and β-blockers used in glaucoma generate competitive antagonism on the same adrenergic receptor when used ...
Jorge Enrique Machado-Alba, Valentina Hoyos-Soto   +1 more
doaj  

Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein

, 2023
Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Slava Bekker, Vladimir Yarov‐Yarovoy, Colleen E. Clancy, Yang K. Xiang, Igor Vorobyov   +8 more
openalex   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets

International Journal of Endocrinology, 2018
Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present ...
Silvano Piovan, Audrei Pavanello, Giuliana Maria Ledesma Peixoto, Camila Cristina Ianoni Matiusso, Ana Maria Praxedes de Moraes, Isabela Peixoto Martins, Ananda Malta, Kesia Palma-Rigo, Claudinéia Conationi da Silva Franco, Paula Gimenez Milani, Antonio Sérgio Dacome, Silvio Claudio da Costa, Paulo Cezar de Freitas Mathias, Cecília Edna Mareze-Costa   +13 more
doaj   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Persistent bothersome urinary frequency following stereotactic body radiation therapy for clinically localized prostate cancer: rationale for prophylactic β3-agonist in men with elevated baseline international prostate symptom scores

Frontiers in Oncology
IntroductionStereotactic body radiation therapy (SBRT) for clinically localized prostate cancer has been associated with prolonged acute obstructive and irritative lower urinary tract symptoms (LUTS).
Jennifer Zack, Min Ji Koh, Emily Lindbloom, Timothy O’Connor, Kelly Gaudian, Alan Zwart, Malika Danner, Deepak Kumar, Simeng Suy, Ryan Hankins, Sean Collins   +10 more
doaj   +1 more source