Results 121 to 130 of about 92,710 (320)

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg, JoAnn Slack, Darko Stefanovski, DeAnna Theiss, Klaus Hopster   +4 more
wiley   +1 more source

A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.

Journal of Lipid Research, 1988
The beta-adrenergic receptors of isolated human fat cells were identified using a new hydrophilic beta-adrenergic radioligand (+/-)[3H]CGP-12177. The results were compared with those from [3H]dihydroalprenolol binding to fat cells and membranes.
D Lacasa, P Mauriège, M Lafontan, M Berlan, Y Giudicelli   +4 more
doaj  

Short Communication: Beta-adrenergic agonists alter oxidative phosphorylation in primary myoblasts [PDF]

, 2022
Renae L Sieck, Leah K Treffer, Anna Fuller, Martônio Ponte Viana, Oleh Khalimonchuk, Ty B Schmidt, Dustin T Yates, Jessica L. Petersen   +7 more
openalex   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Persistent Lactate Elevation in a Patient with Asthma Exacerbation and a Congenital Portosystemic Shunt: A Case Report and Literature Review

Reports
Background and Clinical Significance: When lactate production surpasses the body’s clearance capacity, hyperlactatemia (lactate ≥ 2 mmol/L) or lactic acidosis (lactate ≥ 4 mmol/L) can develop.
Wing Fai Li, Bailey Fink, Rehnuma Khan, Xinmiao Luo, Muhammad Fahimuddin   +4 more
doaj   +1 more source

Hyperhidrosis: don't sweat it

Internal Medicine Journal, EarlyView.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

New Aspects of 2-Adrenergic Agonists

Journal of Bahria University Medical and Dental College, 2015
Beta2-adrenergic receptor agonists is a class of medications that act on the 2-adrenergic receptors. They are mostly used to treat asthma and other respiratory problems at present.
Touseef Sayyar
doaj  

Beta-adrenergic agonists stimulate the synthesis of noncontractile but not contractile proteins in cultured myocytes isolated from adult rat heart. [PDF]

, 1990
I. Dubus, Jane‐Lise Samuel, F. Marotte, Claude Delcayre, L. Rappaport   +4 more
openalex   +1 more source

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Elucidation of a dynamic interplay between guanine nucleotide and the ternary complex of a beta-adrenergic receptor, its agonist and stimulatory G protein [PDF]

, 2023
Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Borislava Bekker, Vladimir Yarov‐Yarovoy, Colleen E. Clancy, Yang Xiang, Igor Vorobyov   +9 more
openalex   +1 more source