Results 11 to 20 of about 116,135 (274)

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

open access: yesPLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon   +4 more
doaj   +1 more source

Adrenergic effects on hypothalamic activity: Alpha and beta agonists and antagonists [PDF]

open access: yesBulletin of the Psychonomic Society, 1975
Dose-response curves were plotted to analyze the effects of adrenergic agonists and antagonists upon neural activity within the hypothalamus. Multiple unit activity (MUA) was recorded following microinjection of the drugs directly into the recording site through a hollow recording electrode.
Hugh E. Criswell, Robert A. Levitt
openaire   +1 more source

Welfare traits of cattle castrated immunologically and fed beta-adrenergic agonists [PDF]

open access: yesAnimal Bioscience, 2021
Objective This work was carried out to evaluate the effects of zilpaterol hydrochloride (ZH) and ractopamine hydrochloride (RH) combined with immunocastration on the welfare traits of feedlot Nellore cattle. Methods Ninety-six Nellore males (average body
Luciane Silva Martello   +8 more
doaj   +1 more source

Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1984
Exposure of several mammalian cell lines to isoproterenol resulted in a desensitization of the beta-adrenergic receptor-adenylate cyclase system in membranes isolated from the cells. Under the experimental conditions chosen, desensitization was accompanied by a minimal loss of beta-receptors.
S, Kassis, P H, Fishman
openaire   +2 more sources

LBMON186 Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes For The Beta 2-adrenergic Receptor With Implications In The Treatment Of Asthma

open access: yesJournal of the Endocrine Society, 2022
Abstract Asthma involves chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Treatment include agonists of the beta 2-AR, a GPCR that induces the Gs/cAMP pathway leading to ASM relaxation. These agonists can also promote severe side effects which have been correlated with beta-arrestins (barr) activation ...
Pascali, Francesco D   +10 more
openaire   +1 more source

Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.

open access: yesJournal of Lipid Research, 1981
The aim of this study was to define the role of the alpha-adrenergic receptor in the regulation of lipolysis by human adipocytes. Glycerol production by isolated human adipocytes was stimulated by the pure beta-adrenergic agonist isoproterenol in a dose ...
E E Wright, E R Simpson
doaj   +1 more source

Beta-1 and not beta-3-adrenergic receptors may be the primary regulator of human brown adipocyte metabolism.

open access: yesJournal of Clinical Endocrinology and Metabolism, 2019
PURPOSE Brown adipose tissue (BAT) activation in humans has gained interest as a potential target for treatment of obesity and insulin resistance. In rodents, BAT is primarily induced through beta-3-adrenergic receptor (ADRB3) stimulation, whereas the ...
M. J. Riis-Vestergaard   +5 more
semanticscholar   +1 more source

Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease

open access: yesNeurobiology of Disease, 2020
Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one of ...
Andrew K. Evans   +5 more
doaj   +1 more source

The (--)[3H]dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites

open access: yesJournal of Lipid Research, 1982
In rat adipocyte membranes, both beta-adrenergic agonists and beta-adrenergic antagonists competed with (--)[3H]dihydroalprenolol for high affinity (KD 2-4 nM) and low capacity binding sites.
E M Dax, J S Partilla, R I Gregerman
doaj   +1 more source

Comparative Pharmacoepidemiological Assessment of Antihypertensive Drugs Administration Structure in Pregnant Women in Routine Medical Practice in Kursk and Chisinau

open access: yesРациональная фармакотерапия в кардиологии, 2022
Aim. To study the structure of antihypertensive drugs prescription in pregnant women in routine practice in Kursk and Chisinau.Material and methods. The study design was observational descriptive cross-sectional.
S. V. Povetkin   +6 more
doaj   +1 more source

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