Results 21 to 30 of about 945,289 (264)

Safety and efficacy of beta-3 adrenergic agonists in treating neurogenic lower urinary tract dysfunction: A systematic review and meta-analysis [PDF]

Investigative and Clinical Urology
Purpose: To evaluate efficacy and safety of beta-3 adrenergic agonists in adults with neurogenic lower urinary tract dysfunction. Materials and Methods: According to a protocol (CRD42022350079), we searched multiple data sources for published and ...
Mohamed Medhat Elkhashab, Abdullah Mari Alqahtani, Myung Ha Kim, Jinu Kim, Jang Hwan Kim, Jae Hung Jung   +5 more
doaj   +1 more source

Trafficking of β2-adrenergic receptors: insulin and β-agonists regulate internalization by distinct cytoskeletal pathways [PDF]

Journal of Cell Science, 2004
Insulin and β-adrenergic agonists stimulate a rapid phosphorylation and sequestration of the β2-adrenergic receptors (β2ARs). Although the expectation was that a common pathway would be involved in the trafficking of the β2AR in response to either hormone, studies reported herein show the existence of unique cytoskeletal requirements for ...
Elena, Shumay, Shai, Gavi, Hsien-yu, Wang, Craig C, Malbon   +3 more
openaire   +2 more sources

An assay for beta-adrenergic receptors in isolated human fat cells.

Journal of Lipid Research, 1982
The beta-adrenergic receptors have been characterized in isolated human adipocytes using a potent beta-adrenergic antagonist (-)-[3H]dihydroalprenolol.
P Engfeldt, P Arner, H Wahrenberg, J Ostman   +3 more
doaj   +1 more source

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source

Evidence from in vitro differentiating cells that adrenoceptor agonists can increase uncoupling protein mRNA level in adipocytes of adult humans: an RT-PCR study

Journal of Lipid Research, 1996
In vivo data have suggested that adrenergic signals can reactivate dormant brown adipocytes in adult humans. We report here a system based on primary cultures of perirenal adipocytes from human adults and reverse transcription-PCR of uncoupling protein ...
O Champigny, D Ricquier
doaj   +1 more source

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Open Chemistry, 2020
β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their
Ružena Čižmáriková, Jindra Valentová, Renáta Horáková   +2 more
doaj   +1 more source

Prolonged β-Agonist Infusion Does Not Induce Desensitization or Down-Regulation of β-Adrenergic Receptors in Newborn Sheep [PDF]

Pediatric Research, 1992
In adult animals, prolonged beta-agonist exposure leads to down-regulation of beta-adrenergic receptors and desensitization. Prior evidence from our lab suggests that this may not occur in developing animals. To study this, we measured the response to graded epinephrine infusion [2.7, 5.5, 13.6, 27.3 mumol/(kg.min), (0.5, 1.0, 2.5, 5.0 micrograms/(kg ...
H M, Stein, K, Oyama, R, Sapien, B A, Chappell, J F, Padbury   +4 more
openaire   +2 more sources

In Vitro Effects of Beta-2 Agonists on Skeletal Muscle Differentiation, Hypertrophy, and Atrophy

World Allergy Organization Journal, 2012
Background Beta-2 agonists are widely used in the treatment of asthma and chronic obstructive pulmonary disease for their effect on airway smooth muscle relaxation.
Francesca Wannenes, PhD, Loretta Magni, PhD, Matteo Bonini, MD, PhD, Ivan Dimauro, PhD, Daniela Caporossi, PhD, Costanzo Moretti, MD, Sergio Bonini, MD   +6 more
doaj   +1 more source

Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox [PDF]

Journal of Clinical Investigation, 2003
beta-adrenergic receptors (betaARs) relax airway smooth muscle and bronchodilate, but chronic beta-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated betaAR genes (betaAR-/-) and transgenic mice overexpressing airway ...
Dennis W, McGraw, Khalid F, Almoosa, Richard J, Paul, Brian K, Kobilka, Stephen B, Liggett   +4 more
openaire   +2 more sources

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source