Results 21 to 30 of about 25,120 (238)

An assay for beta-adrenergic receptors in isolated human fat cells.

Journal of Lipid Research, 1982
The beta-adrenergic receptors have been characterized in isolated human adipocytes using a potent beta-adrenergic antagonist (-)-[3H]dihydroalprenolol.
P Engfeldt, P Arner, H Wahrenberg, J Ostman   +3 more
doaj   +1 more source

Evidence from in vitro differentiating cells that adrenoceptor agonists can increase uncoupling protein mRNA level in adipocytes of adult humans: an RT-PCR study

Journal of Lipid Research, 1996
In vivo data have suggested that adrenergic signals can reactivate dormant brown adipocytes in adult humans. We report here a system based on primary cultures of perirenal adipocytes from human adults and reverse transcription-PCR of uncoupling protein ...
O Champigny, D Ricquier
doaj   +1 more source

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Open Chemistry, 2020
β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their
Ružena Čižmáriková, Jindra Valentová, Renáta Horáková   +2 more
doaj   +1 more source

Prolonged β-Agonist Infusion Does Not Induce Desensitization or Down-Regulation of β-Adrenergic Receptors in Newborn Sheep [PDF]

Pediatric Research, 1992
In adult animals, prolonged beta-agonist exposure leads to down-regulation of beta-adrenergic receptors and desensitization. Prior evidence from our lab suggests that this may not occur in developing animals. To study this, we measured the response to graded epinephrine infusion [2.7, 5.5, 13.6, 27.3 mumol/(kg.min), (0.5, 1.0, 2.5, 5.0 micrograms/(kg ...
H M, Stein, K, Oyama, R, Sapien, B A, Chappell, J F, Padbury   +4 more
openaire   +2 more sources

In Vitro Effects of Beta-2 Agonists on Skeletal Muscle Differentiation, Hypertrophy, and Atrophy

World Allergy Organization Journal, 2012
Background Beta-2 agonists are widely used in the treatment of asthma and chronic obstructive pulmonary disease for their effect on airway smooth muscle relaxation.
Francesca Wannenes, PhD, Loretta Magni, PhD, Matteo Bonini, MD, PhD, Ivan Dimauro, PhD, Daniela Caporossi, PhD, Costanzo Moretti, MD, Sergio Bonini, MD   +6 more
doaj   +1 more source

Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox [PDF]

Journal of Clinical Investigation, 2003
beta-adrenergic receptors (betaARs) relax airway smooth muscle and bronchodilate, but chronic beta-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated betaAR genes (betaAR-/-) and transgenic mice overexpressing airway ...
Dennis W, McGraw, Khalid F, Almoosa, Richard J, Paul, Brian K, Kobilka, Stephen B, Liggett   +4 more
openaire   +2 more sources

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source

Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines

BMC Cancer, 2004
Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz, Yu Qiang, Plummer Howard K, Schuller Hildegard M   +3 more
doaj   +1 more source

Effects of catecholamines on volemic replacement with saline solution and the impact on heart rate variability in rabbits subjected to hemorrhage. A study by spectral analysis [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To verify the effects of different catecholamines on volemic expansion and on the autonomic nervous system in rabbits that were subjected to hemorrhage.METHODS: Twenty four rabbits subjected to hemorrhage (with a 25% loss of blood volume) and ...
José Mariano Soares de Moraes, Matheus Fachini Vane, Denise de Fátima Rodrigues, Cristiano Teixeira Mostarda, Thiago Soares Mendes Moreira de Moraes, Lucas Fachini Vane, Eliana Marisa Ganem, Ismar Lima Cavalcanti, Norma Sueli Pinheiro Módolo, Luiz Antonio Vane   +9 more
doaj   +1 more source

β‐Agonist‐induced constitutive β₂‐adrenergic receptor activity in bovine tracheal smooth muscle [PDF]

British Journal of Pharmacology, 2000
According to the two state receptor model, the β2‐adrenergic receptor (β2‐AR) isomerizes between an inactive state and a constitutively active state, which couples to the stimulatory G‐protein in the absence of agonist. In bovine tracheal smooth muscle (BTSM), we investigated the effect of short and long term β2‐AR activation by fenoterol on ...
de Vries, Berber, Meurs, Herman, Roffel, Ad F., Elzinga, Carolina R.S., Hoiting, B.H., de Vries, M.M.L., Zaagsma, Johan   +6 more
openaire   +2 more sources