Results 31 to 40 of about 116,135 (274)

Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox [PDF]

Journal of Clinical Investigation, 2003
beta-adrenergic receptors (betaARs) relax airway smooth muscle and bronchodilate, but chronic beta-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated betaAR genes (betaAR-/-) and transgenic mice overexpressing airway ...
Dennis W, McGraw, Khalid F, Almoosa, Richard J, Paul, Brian K, Kobilka, Stephen B, Liggett   +4 more
openaire   +2 more sources

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source

Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines

BMC Cancer, 2004
Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz, Yu Qiang, Plummer Howard K, Schuller Hildegard M   +3 more
doaj   +1 more source

Effects of catecholamines on volemic replacement with saline solution and the impact on heart rate variability in rabbits subjected to hemorrhage. A study by spectral analysis [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To verify the effects of different catecholamines on volemic expansion and on the autonomic nervous system in rabbits that were subjected to hemorrhage.METHODS: Twenty four rabbits subjected to hemorrhage (with a 25% loss of blood volume) and ...
José Mariano Soares de Moraes, Matheus Fachini Vane, Denise de Fátima Rodrigues, Cristiano Teixeira Mostarda, Thiago Soares Mendes Moreira de Moraes, Lucas Fachini Vane, Eliana Marisa Ganem, Ismar Lima Cavalcanti, Norma Sueli Pinheiro Módolo, Luiz Antonio Vane   +9 more
doaj   +1 more source

Comparison of antimuscarinic drugs to beta adrenergic agonists in overactive bladder: A literary review

Current Urology, 2021
. Background:. The purpose of this study was to carry an extended literature review to compare antimuscarnics with beta adrenergic agonists (mirabegron) in treatment of overactive bladder. Materials and methods:.
Mudassir M. Wani, Mohammad I. Sheikh, Tahir Bhat, Zubair Bhat, Arshad Bhat   +4 more
doaj   +1 more source

β‐Agonist‐induced constitutive β₂‐adrenergic receptor activity in bovine tracheal smooth muscle [PDF]

British Journal of Pharmacology, 2000
According to the two state receptor model, the β2‐adrenergic receptor (β2‐AR) isomerizes between an inactive state and a constitutively active state, which couples to the stimulatory G‐protein in the absence of agonist. In bovine tracheal smooth muscle (BTSM), we investigated the effect of short and long term β2‐AR activation by fenoterol on ...
de Vries, Berber, Meurs, Herman, Roffel, Ad F., Elzinga, Carolina R.S., Hoiting, B.H., de Vries, M.M.L., Zaagsma, Johan   +6 more
openaire   +2 more sources

The Influence of Supplemental Zinc and Ractopamine Hydrochloride on the Performance and Longissimus Thoracis Proteome of Finishing Beef Steers

Meat and Muscle Biology, 2022
To determine how Zn and ractopamine hydrochloride (RAC) supplementation affect the longissimus thoracis muscle proteome in beef cattle, 48 high percentage Angus steers (494±18.2 kg) were utilized in a 2×2 factorial study design.
Elisabeth J. Huff-Lonergan, Elizabeth Messersmith, Katherine G. Hochmuth, Matthew D. Schulte, Stephanie L. Hansen   +4 more
doaj   +2 more sources

MODERN POSSIBILITIES OF MEDICAL TREATMENT OF OVERACTIVE BLADDER IN WOMEN

Медицинский совет, 2017
Overactive bladder (OAB) is a serious urination disorder which affects at least 17% of the population above 40 years old, of which 56% are women and 44% are men. M-cholinoblockers are the first line therapy and the main treatment for OAB.
I. A. Apolikhina, A. S. Chochueva, A. S. Saidova, E. A. Gorbunova   +3 more
doaj   +1 more source

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.

Journal of Biological Chemistry, 1988
The beta-adrenergic receptor (beta AR) kinase is a recently discovered enzyme which specifically phosphorylates the agonist-occupied form of the beta-adrenergic receptor.
J. Benovic, C. Staniszewski, Federico Mayor, M. Caron, R. Lefkowitz   +4 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source