Results 221 to 230 of about 92,710 (320)
British Journal of Pharmacology, Volume 182, Issue 7, Page 1487-1507, April 2025.Abstract Background and Purpose Sarcoplasmic reticulum Ca2+‐ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local cAMP signals and protein kinase A (PKA) activity essential for cardiac function.
Zhenduo Zhu +11 more
wiley +1 more source
Brown and Beige Adipose Tissue: One or Different Targets for Treatment of Obesity and Obesity-Related Metabolic Disorders? [PDF]
Int J Mol SciKononova YA, Tuchina TP, Babenko AY.
europepmc +1 more source
Interrelatinoship between alpha- and beta-adrenergic agonists and histamine in canine airways
, 1981 A. R. Leff, Núbia Muñóz
openalex +1 more source
How ‘miracle’ weight‐loss semaglutide promises to change medicine but can we afford the expense?
British Journal of Pharmacology, Volume 182, Issue 8, Page 1651-1670, April 2025.Obesity is a complex and growing global concern, affecting one in eight individuals and compromising health, quality of life and life expectancy. It carries significant metabolic, cardiovascular, oncological, hepatorenal, skeletal and psychiatric risks, imposing substantial costs on health‐care systems.
Ralf Weiskirchen, Amedeo Lonardo
wiley +1 more source
Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET). [PDF]
World J UrolHedlund P +4 more
europepmc +1 more source
Chemical Biology &Drug Design, Volume 105, Issue 4, April 2025.The Mechanism of Dexmedetomidine in Treating Myocardial Ischemia–Reperfusion Injury via the Sirt1/Foxo3a Pathway. ABSTRACT Myocardial ischemia–reperfusion injury (MIRI) significantly affects the prognosis of cardiac surgery patients. The anesthetic dexmedetomidine (Dex) has shown protective effects against ischemia–reperfusion injury in cardiomyocytes;
Hanlin Ding +6 more
wiley +1 more source
Computational Methods for the Discovery and Optimization of TAAR1 and TAAR5 Ligands. [PDF]
Int J Mol SciScarano N +3 more
europepmc +1 more source
Chemical Biology &Drug Design, Volume 105, Issue 4, April 2025.This diagram illustrates the protective effects of dexmedetomidine (Dex) and thrombopoietin (TPO) against hypoxia/reoxygenation (H/R)‐induced injury in AC16 cells. Both treatments activate signaling pathways, including stem cell pluripotency, TNF, TGF‐β, and MAPK, promoting cell proliferation and inhibiting apoptosis.
Cuiyan Xing +3 more
wiley +1 more source
Glaucoma: Current and New Therapeutic Approaches. [PDF]
BiomedicinesLee HP +4 more
europepmc +1 more source