Results 41 to 50 of about 92,710 (320)
Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions
British Journal of Clinical Pharmacology, EarlyView., 2023 Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius +2 more
wiley +1 more source
Open Chemistry, 2020 β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their
Ružena Čižmáriková +2 more
doaj +1 more source
American Journal of Physiology - Lung cellular and Molecular Physiology, 2007 Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants and children worldwide. We wished to determine whether intratracheal administration of beta-agonists improved alveolar fluid clearance (AFC) across the distal ...
I. Davis +6 more
semanticscholar +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Current Urology, 2021 . Background:. The purpose of this study was to carry an extended literature review to compare antimuscarnics with beta adrenergic agonists (mirabegron) in treatment of overactive bladder. Materials and methods:.
Mudassir M. Wani +4 more
doaj +1 more source
A pattern mixture model for a paired $2\times2$ crossover design [PDF]
IMS Collections 2008, Vol. 1, 257-271, 2008 When conducting a paired $2\times2$ crossover design, each subject is paired with another subject with similar characteristics. The pair is then randomized to the same sequence of two treatments. That is, the two subjects receive the first experimental treatment, and then they cross over and receive the other experimental treatment(s).
arxiv +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Frontiers in Pharmacology, 2020 Millions of patients suffer from asthma worldwide. However, the first-line drugs used to treat asthma, namely, the beta-adrenergic receptors agonists (β-agonists), are not recommended for use as monotherapy because of their severe dose-related side ...
Simeng Chu +7 more
doaj +1 more source
Frontiers in Physiology, 2015 Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj +1 more source
Meat and Muscle Biology, 2022 To determine how Zn and ractopamine hydrochloride (RAC) supplementation affect the longissimus thoracis muscle proteome in beef cattle, 48 high percentage Angus steers (494±18.2 kg) were utilized in a 2×2 factorial study design.
Elisabeth J. Huff-Lonergan +4 more
doaj +2 more sources