Results 51 to 60 of about 50,860 (258)

Cost-effectiveness of glaucoma management with monotherapy medications in Egypt

Journal of Advanced Pharmaceutical Technology & Research, 2017
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic ...
Amal Abd-Elaal El-Khamery, Amir Ibrahim Mohamed, Hassan Eisa Hassan Swify, Alaa Ibrahim Mohamed   +3 more
doaj   +1 more source

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles [PDF]

, 2018
Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/
Andrades-Lagos, J., Campanini-Salinas, J., Lorca, M., Mella, J., Morales-Verdejo, C., Recabarren-Gajardo, G., Soto-Delgado, J., Vásquez-Velásquez, D.   +7 more
core   +2 more sources

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Anticholinergic therapy for acute asthma in children. [PDF]

, 2012
Inhaled anticholinergics as single agent bronchodilators (or in combination with beta(2)-agonists) are one of the several medications available for the treatment of acute asthma in ...
Beakes, Beck, Benito Fernandez, Bever, Bratteby, British Thoracic Society, Brown, Browne, Calvo, Cook, Craven, Cugell, DeStefano, Ducharme, Everard, Goggin, Gross, Guill, Hayday, Iramain, Lew, Lin, Lung, Mallol, McDonald, Mirsadraee, National Asthma Council Australia, Ni, Plotnick, Pulejo, Quereshi, Qureshi, Rayner, Reisman, Rodrigo, Schuh, Sienra Monge, Storms, Storr, Tal, Timsit, Ulrik, Undem, Wade, Ward, Ward, Yeung, Youngchaiyud, Zimmerman, Zorc   +49 more
core   +2 more sources

Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints

Advanced Robotics Research, EarlyView.
This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito, Byeongwook Jo, Tomohiro Morita, Shota Noda, Minghao Nie, Shoji Takeuchi   +5 more
wiley   +1 more source

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

Proceedings of the National Academy of Sciences, 1986
beta-Adrenergic receptor kinase (beta-AR kinase) is a cytosolic enzyme that phosphorylates the beta-adrenergic receptor only when it is occupied by an agonist [Benovic, J. Strasser, R. H., Caron, M. G. & Lefkowitz, R. J. (1986) Proc. Natl. Acad. Sci.
Strasser, RH, Benovic, JL, Caron, MG, Lefkowitz, RJ   +3 more
openaire   +3 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

[Adrenergic beta-agonist intoxication].

Acta medica portuguesa, 2012
The authors describe two clinical cases (father and daughter), observed in the Hospital Urgency with distal tremors, anxiety, palpitations, nausea, headaches and dizziness, two hours after ingestión of cow liver. They also had leucocytosis (with neutrophylia), hypokalemia and hyperglycaemia. After treatment with potassium i.v.
Paulo, Carrola, Nuno, Devesa, José Manuel, Silva, Fernando, Ramos, Mário B, Alexandrino, José J, Moura   +5 more
openaire   +1 more source

Micro-RNA family that modulates fibrosis and uses thereof [PDF]

, 2017
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core   +1 more source