Results 51 to 60 of about 92,710 (320)
BMC Cancer, 2004 Background Previous research has indicated that at various organ sites there is a subset of adenocarcinomas that is regulated by beta-adrenergic and arachidonic acid-mediated signal transduction pathways.
Cakir Yavuz +3 more
doaj +1 more source
Energy Transport and its Function in Heptahelical Transmembrane Proteins [PDF]
arXiv, 2022 Photoproteins such as bacteriorhodopsin (bR) and rhodopsin (Rho) need to effectively dissipate photoinduced excess energy to prevent their damage. Another well-studied G protein-coupled receptor (GPCR) containing 7 transmembrane (TM) helices is the B2 adrenergic receptor (B2AR), for which energy dissipation paths have been linked with allosteric ...
arxiv
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox [PDF]
Journal of Clinical Investigation, 2003 beta-adrenergic receptors (betaARs) relax airway smooth muscle and bronchodilate, but chronic beta-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated betaAR genes (betaAR-/-) and transgenic mice overexpressing airway ...
Khalid F. Almoosa +4 more
openaire +3 more sources
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]
arXiv, 2022 Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv
MODERN POSSIBILITIES OF MEDICAL TREATMENT OF OVERACTIVE BLADDER IN WOMEN
Медицинский совет, 2017 Overactive bladder (OAB) is a serious urination disorder which affects at least 17% of the population above 40 years old, of which 56% are women and 44% are men. M-cholinoblockers are the first line therapy and the main treatment for OAB.
I. A. Apolikhina +3 more
doaj +1 more source
Implication of Central β<sub>2</sub> Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease. [PDF]
Arch Pharm (Weinheim)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive onset of symptoms, including memory loss, accompanied by other neurological impairments. This progression is attributed to the deterioration of neuronal connections and a decrease in neurotransmission.
Wang A +3 more
europepmc +2 more sources
Advanced Theory and Simulations, EarlyView.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source
Advanced Science, EarlyView.Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li +21 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2004 We report the 3D structure of human beta2 adrenergic receptor (AR) predicted by using the MembStruk first principles method. To validate this structure, we use the HierDock first principles method to predict the ligand-binding sites for epinephrine and ...
P. Freddolino +7 more
semanticscholar +1 more source
Exploring barriers to utilizing local agricultural products in the catering industry
Agribusiness, EarlyView.Abstract Both the proportion and expenditure of dining out and takeaway in Taiwan have been increasing year by year. This study investigates the factors influencing the catering service providers (CSPs) procurement of domestically produced or imported food materials.
Wan‐Yu Liu +2 more
wiley +1 more source