Results 71 to 80 of about 50,860 (258)
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core +1 more source
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, EarlyView.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
BRONCHIAL ASTHMA THERAPY IN SMART-REGIME: STUDIES IN REAL CLINICAL PRACTICE
Медицинский совет, 2016 Despite considerable progress in development of effective therapeutic means, numerous studies are indicative of the insufficient BA control level resulting in reduction of patient life quality as well as to the high risk of disease exacerbations.
R. S. FASSAKHOV
doaj +1 more source
Analytica Chimica Acta, 2007 The number of substances with beta-agonistic activity, illegally introduced in meat production or in sports doping as anabolic or beta-blocking agents is increasing. Analytical methods suited for their multianalyte detection are thus necessary. In this perspective, receptor assays were developed.
Danyi, Sophie +5 more
openaire +2 more sources
The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]
, 2011 BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Aaron +32 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty +4 more
wiley +1 more source
Journal of Lipid Research, 1988 The beta-adrenergic receptors of isolated human fat cells were identified using a new hydrophilic beta-adrenergic radioligand (+/-)[3H]CGP-12177. The results were compared with those from [3H]dihydroalprenolol binding to fat cells and membranes.
D Lacasa +4 more
doaj +1 more source
Discover Mental Health, 2023 Schizophrenia is a debilitating condition necessitating more efficacious therapies. Previous studies suggested that schizophrenia development is associated with aberrant synaptic pruning by glial cells.
Ellen R. Bowen +10 more
doaj +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, EarlyView.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source
Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation
Brazilian Journal of Medical and Biological Research, 2001 We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed.
Puscas I. +6 more
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