Results 81 to 90 of about 50,860 (258)

Veterinary treatment of cows with isoxsuprine for a caesarian section may temporarily lead to residues in hair of both cow and calf [PDF]

Isoxsuprine is a beta-agonist that can be used for growth promotion in cattle, but it is also used as registered veterinary medicine. To investigate if veterinary treatment of cows could lead to residues of isoxsuprine in the hair of their newborn calves,
Groot, M.J., Hende, J., van, Lasaroms, J.J.P., Nielen, M.W.F.   +3 more
core   +1 more source

Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]

, 2012
Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng, FRANCHITTO, Antonio, GAUDIO, EUGENIO, Gianfranco D. Alpini, Guido Carpino, Hannah E. Shine, Heather L. Francis, Julie K. Venter, Kimberly K. Baker, MANCINELLI, ROMINA, Mellanie A. White, ONORI, PAOLO, RENZI, ANASTASIA, Sharon Demorrow, Taylor C. Francis, Yoshiyuki Ueno   +15 more
core   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]

, 2006
Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas, Cirelli, Rosemary, Foster, Gayle C., Hastie, Annette T., Hawkins, Gregory A., Peters, Stephen P., Rybinski, Katherine A., Wu, Min, Zangrilli, James G.   +8 more
core   +1 more source

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]

, 2013
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton, Donald H Maurice, Dreiza, George S Baillie, Hayes, Li, Louisa CY Lee, Shenoy, Tavalin   +8 more
core   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Topical administration of adrenergic receptor pharmaceutics and nerve growth factor

Clinical Ophthalmology, 2010
Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor ...
Jena J Steinle
doaj  

Pharmacogenetics of inhaled long-acting beta2-agonists in asthma:a systematic review [PDF]

, 2018
Background: Long-acting beta2-agonists (LABA) are recommended in asthma therapy; however, not all asthma patients respond well to LABA. We performed a systematic review on genetic variants associated with LABA response in patients with asthma.
Ambrose, Basu, Bleecker, Bleecker, Bleecker, Bonini, Calhoun, Cariaso, Cazzola, Chung, Cooper, Currie, Drazen, Drysdale, Farzan, Giubergia, Harada, Jabbal, Jabbal, Kalra, Kersten, Kim, Kim, Konno, Lee, Lee, Lemanske, Leusink, Leusink, Li, Lima, Lipworth, Lipworth, Little, Maagdenberg, Mak, Mak, Manning, Moher, Nyenhuis, O'Byrne, Ortega, Ortega, Ortega, Palmer, Peters, Petrovic-Stanojevic, Rabe, Rebordosa, Reihsaus, Salpeter, Sears, Simons, Slankard, Soleimani, Spector, Tan, Taylor, Taylor, Tonk, Turner, Vijverberg, Wechsler, Wechsler, Wijesinghe, Wu, Yancey, Yawn, Zuurhout   +68 more
core   +3 more sources

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Journal of Neuroinflammation
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in ...
Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo   +12 more
doaj   +1 more source