Results 241 to 250 of about 111,593 (328)

β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia. [PDF]

open access: yesAm J Physiol Heart Circ Physiol
Jacob DW   +8 more
europepmc   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

open access: yesGlia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc   +10 more
wiley   +1 more source

6‐Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Human seminal vesicles present basal release of epithelium‐derived 6‐nitrodopamine (6‐ND) and this catecholamine potentiates noradrenaline‐induced contractions. Since nitric oxide synthase (NOS) activation is a determining factor involved in 6‐ND biosynthesis, this study aimed to investigate which NOS isoform is responsible for the 6‐ND ...
José Britto‐Júnior   +12 more
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran   +9 more
wiley   +1 more source

Lipedema: Progress, Challenges, and the Road Ahead

open access: yesObesity Reviews, Volume 26, Issue 10, October 2025.
ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley   +1 more source

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