Results 41 to 50 of about 115,087 (327)

Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength [PDF]

, 2014
Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone
Apel, Arai, Aro, Aspenberg, Baek, Bliziotes, Bonnet, Bonnet, Bostrom, Chenu, Cherruau, Chhabra, Ding, Elefteriou, Elefteriou, Graham, Hara-Irie, Harrison, He, Hohmann, Jeyabalan, Kajimura, Kondo, Long, Mach, Madsen, Marenzana, Marsell, Minkowitz, Moran, Morgan, Pierroz, Pullar, Reid, Rodrigues, Serre, Strömberg, Takeda, Takeda, Togari   +39 more
core   +2 more sources

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Anglin IE, Boris Schlenker, Chang L, Chon JK, Christ GJ, Christian G. Stief, Christian Gratzke, Erdogru T, Frank Strittmatter, Glassman DT, Golomb E, Johanna Göttinger, Kanagawa K, Karl-Erik Andersson, Kyprianou N, Kyprianou N, Kyprianou N, Lucia MS, Luthin GR, Marinese D, Maroni PD, Martin Hennenberg, McCubrey JA, McVary KT, Michel MC, Oliver Reich, Petter Hedlund, Ricarda M. Bauer, Roehrborn CG, Roehrborn CG, Royuela M, Royuela M, Schilit S, Schwinn DA, Shimada K, Srinivasan D, Turkeri LN, Xiao L, Zhang H, Zhang Z   +39 more
core   +1 more source

Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]

, 2006
Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A., Rankin, A.C., Redpath, C., Workman, A.J.   +3 more
core   +1 more source

Management of Hypertrophic Obstructive Cardiomyopathy with Concurrent Hypertension and Intracerebral Haemorrhage: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Hypertrophic Obstructive Cardiomyopathy (HOCM) is primarily a hereditary genetic disorder that presents difficulties in managing hypertension using a wide range of antihypertensive medications.
Sangram Mangudkar, Varun lingineni, Vijayashree S Gokhale, Ponvijaya M Yadav, Ankit Shokeen   +4 more
doaj   +1 more source

Co-Crystallization Adducts of Carvedilol with Carboxylic Acids: Design and Characterization

Proceedings
Carvedilol (CARV) belongs to the group of non-selective beta and alpha-1 adrenergic receptor antagonists and is indicated for hypertension and chronic heart failure [...]
Ema-Teodora Nițu, Luciana Buliga, Ioana Mitrofan, Amalia Ridichie, Cornelia Muntean, Ionuţ Ledeţi, Adriana Ledeți, Laura Sbârcea   +7 more
doaj   +1 more source

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Autonomic regulation therapy to enhance myocardial function in heart failure patients: the ANTHEM-HFpEF study. [PDF]

, 2017
BackgroundApproximately half of the patients presenting with new-onset heart failure (HF) have HF with preserved left ventricular ejection fraction (HFpEF) and HF with mid-range left ventricular ejection fraction (HFmrEF).
Amurthur, Badri, Anand, Inder S, Ardell, Jeffrey L, DiCarlo, Lorenzo A, KenKnight, Bruce H, Kumar, H Uday, Libbus, Imad, Mittal, Sanjay, Premchand, Rajendra K   +8 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Use of Beta-Blockers as a First-Line Treatment for Primary Hypertension

Hearts
Background: Even though beta-blockers had been used as a first-line therapy for hypertension, since the late 1960s, the Eighth Joint National Committee, JNC 8, decided to recommend them no longer.
Maryam Izadi, Shiva Shafabakhsh, Amir Mirnateghi   +2 more
doaj   +1 more source