Results 91 to 100 of about 121,835 (341)
Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
Clinical Interventions in Aging, 2011 Masaki Yoshida1, Junzo Kudoh2, Yukio Homma3, Kazuki Kawabe41Department of Medical Informatics, 2Department of Urology, Japan Labor Health and Welfare Organization, Kumamoto Rosai Hospital, Kumamoto, Japan; 3Department of Urology, Graduate School of ...
Yoshida M, Kudoh J, Homma Y, Kawabe K
doaj
Drug Testing and Analysis, EarlyView.Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup +5 more
wiley +1 more source
Comparing the effects of intravenous injection and intranasal atomisation of detomidine in sheep
Veterinary Medicine and Science, Volume 9, Issue 1, Page 353-362, January 2023., 2023 This paper compares the intravenous and intranasal routs of Detomidine administration in sheep. Abstract Background Detomidine is an α‐2 agonist sedative drug which reduces the release of norepinephrine in nerves. Administering this drug through intranasal (IN) route could cause direct transmission to the central nervous system.
Touran Tahmasbi +3 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt +5 more
wiley +1 more source
Markers for internal neoplasia in the horse
Veterinary Medicine and Science, Volume 9, Issue 1, Page 132-143, January 2023., 2023 The measurement of tumour markers in horses should be performed only in risk groups or in patients with suspicious clinical/laboratory findings (paraneoplastic syndromes). The results should be interpreted with caution as many factors (e.g., young age, pregnancy and inflammation) affect their concentration or activity.
Karolina Drozdzewska, Heidrun Gehlen
wiley +1 more source
β-Adrenergic receptor signaling in prostate cancer
Frontiers in Oncology, 2015 Enhanced sympathetic signaling, often associated with obesity and chronic stress, is increasingly acknowledged as a contributor to cancer aggressiveness.
Peder Rustøen Braadland +4 more
doaj +1 more source
Phenylephrine induces relaxation of longitudinal strips from small arteries of goat legs.
PLoS ONE, 2020 Alpha adrenergic stimulation is known to produce vasoconstriction. We have earlier shown that, in spiral strips of small arteries Phenylephrine (PE) caused vasorelaxation under high nitric oxide (NO) environment.
Kawin Padmaja Marconi +5 more
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Drug Testing and Analysis, EarlyView.Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy +3 more
wiley +1 more source
Models of the cardiac L‐type calcium current: A quantitative review
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 We discuss 73 published models of mammalian ICaL and find differences in gating kinetics, electrochemical driving force, and sensitivity to internal calcium concentrations, leading to considerable variability in their predictions. Abstract The L‐type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital
Aditi Agrawal +7 more
wiley +1 more source
β-adrenergic receptor responsiveness in aging heart and clinical implications
Frontiers in Physiology, 2014 Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the ...
Nicola eFerrara +10 more
doaj +1 more source