Results 1 to 10 of about 18,670 (220)

Multi-Marker Approach in Sepsis: A Clinical Role Beyond SOFA Score [PDF]

Medicina
Background and Objectives: Procalcitonin (PCT), presepsin (PSEP), interferon-λ3 (IFN-λ3), and bioactive adrenomedullin (bio-ADM) are promising sepsis biomarkers.
Gun Hyuk Lee, Hanah Kim, Hee-Won Moon, Yeo-Min Yun, Seungho Lee, Mina Hur   +5 more
doaj   +2 more sources

Adrenomedullin Expression Is Associated With the Severity and Poor Prognosis of Interstitial Lung Disease in Dermatomyositis Patients

Frontiers in Immunology, 2022
ObjectiveTo evaluate adrenomedullin mRNA levels in the peripheral blood mononuclear cells (PBMCs) of patients with dermatomyositis (DM) as well as their correlation with the severity of interstitial lung disease (ILD).MethodsA total of 41 DM patients and
Lifang Ye, Lifang Ye, Yu Zuo, Fang Chen, Yuetong Xu, Yuetong Xu, Puli Zhang, Puli Zhang, Hongxia Yang, Hongxia Yang, Qinglin Peng, Guochun Wang, Guochun Wang, Xiaoming Shu   +13 more
doaj   +1 more source

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

Children, 2022
Adrenomedullin has several properties. It acts as a potent vasodilator, has natriuretic effects, and reduces endothelial permeability. It also plays a role in initiating the early hyperdynamic phase of sepsis. Since its discovery, many articles have been
Anna Solé-Ribalta, Sara Bobillo-Pérez, Iolanda Jordan-García   +2 more
doaj   +1 more source

Adrenomedullin: an important participant in neurological diseases

Neural Regeneration Research, 2020
Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain ...
Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang
doaj   +1 more source

Comparison of nitric oxide and adrenomedullin levels of children with attention deficit hyperactivity disorder and anxiety disorder

Türk Biyokimya Dergisi, 2021
Many studies show that adrenomedullin (ADM) is associated with nitric oxide (NO) and various mechanisms and is involved in the etiopathogenesis of schizophrenia, bipolar disorder and autism by oxidative stress and HPA axis dsyregulation.
Karagöz Yüksel Sümeyra, Doğan Özlem, Elgün Serenay, Kılıç Birim Günay   +3 more
doaj   +1 more source

Serum level of Adrenomedullin in patients with primary knee osteoarthritis; relation to disease severity

Egyptian Rheumatology and Rehabilitation, 2021
Background Adrenomedullin (AM) is a peptide which was suggested to be involved in the pathogenesis of osteoarthritis through its anti-inflammatory and anti-apoptotic effect.
Mervat I. Abd Elazeem, Aya B. S. Ahmed, Rabab A. Mohamed, Enas A. Abdelaleem   +3 more
doaj   +1 more source

The role of mechano-regulated YAP/TAZ in erectile dysfunction

Nature Communications, 2023
Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED). Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment.
Mintao Ji, Dongsheng Chen, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang, Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang, Yongde Xu, Lei Chang   +17 more
doaj   +1 more source

Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)

Pharmaceuticals, 2021
A damaged endothelium is an underlying condition of the many complications of COVID-19 patients. The increased mortality risk associated with diseases that have underlying endothelial dysfunction, such as acute respiratory distress syndrome (ARDS ...
Alice G. Vassiliou, Alexandros Zacharis, Chrysi Keskinidou, Edison Jahaj, Maria Pratikaki, Parisis Gallos, Ioanna Dimopoulou, Anastasia Kotanidou, Stylianos E. Orfanos   +8 more
doaj   +1 more source

Effectiveness of mid-regional pro-adrenomedullin, compared to other biomarkers (including lymphocyte subpopulations and immunoglobulins), as a prognostic biomarker in COVID-19 critically ill patients: New evidence from a 15-month observational prospective study

Frontiers in Medicine, 2023
BackgroundMid-regional pro-adrenomedullin (MR-proADM), an endothelium-related peptide, is a predictor of death and multi-organ failure in respiratory infections and sepsis and seems to be effective in identifying COVID-19 severe forms.
Giorgia Montrucchio, Giorgia Montrucchio, Gabriele Sales, Gabriele Sales, Eleonora Balzani, Davide Lombardo, Alice Giaccone, Giulia Cantù, Giulia D'Antonio, Francesca Rumbolo, Silvia Corcione, Umberto Simonetti, Chiara Bonetto, Marinella Zanierato, Vito Fanelli, Vito Fanelli, Claudia Filippini, Giulio Mengozzi, Luca Brazzi, Luca Brazzi   +19 more
doaj   +1 more source

Hemodynamic and hormonal actions of adrenomedullin

Brazilian Journal of Medical and Biological Research, 2004
Adrenomedullin, a 52-amino acid residue peptide, has numerous biological actions which are of potential importance to cardiovascular homeostasis, growth and development of cardiovascular tissues and bone, prevention of infection, and regulation of body ...
M.G. Nicholls
doaj   +1 more source