Results 91 to 100 of about 18,670 (220)

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu, Huanxin Yang, Jian Su, Jian Zhuang, Jianguang Chen, Shiliang Chen, Xiaoning Zhang, Yuhui Zheng, Zhihong Chen   +8 more
core   +1 more source

Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients. results from the BACH Study (Biomarkers in ACute Heart Failure) [PDF]

, 2013
Objectives: The purpose of this study was to assess the impact of atrial fibrillation (AF) on the performance of mid-region amino terminal pro-atrial natriuretic peptide (MR-proANP) in comparison with the B-type peptides (BNP and NT-proBNP) for diagnosis
Anand I, Anker SD, Christenson R, Clopton P, Daniels LB, DI SOMMA, Salvatore, Filippatos GS, Hartmann O, Hogan C, Maisel A., Mockel M, Mueller C, Neath SX, Ng L, Nowak R, Peacock WF, Ponikowski P, Richards M, Shah K, Wu AH   +19 more
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Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo, Yi‐Chen Wu, Ji‐Min Li, Tz‐Chuen Ju, Tien‐Sheng Tseng   +4 more
wiley   +1 more source

The role of ubiquitination and hepatocyte growth factor-regulated tyrosine kinase substrate in the degradation of the adrenomedullin type I receptor [PDF]

, 2017
Calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM). Although it is known that AM induces internalization of CLR•RAMP2, little is known about the molecular mechanisms ...
A Gullapalli, A Hershko, A Marchese, A Marchese, AC Hanyaloglu, AC Hocke, B Goulet, B Hasdemir, B Hasdemir, B Sehat, B Temmesfeld-Wollbruck, BE Padilla, BL Wolfe, EF Grady, EW Ades, GS Cottrell, IL Goldknopf, J Trejo, JM Bomberger, JN Hislop, JN Hislop, JN Hislop, K Chaturvedi, K Haglund, K Kitamura, K Kuwasako, K Kuwasako, K Shtiegman, KE Longva, KG Bache, KM Caron, L Guery, L Hicke, LM McLatchie, M Christ-Crain, M Christ-Crain, M Komada, M Tanowitz, MR Dores, MR Dores, N Sirisaengtaksin, RH Moore, RM Gage, RT Dackor, S Hippenstiel, S Urbe, SD Brain, SK Shenoy, T Koyama, TA Czyzyk, WP Dunworth, Z Xia   +51 more
core   +2 more sources

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Adrenomedullin and diabetes

World Journal of Diabetes, 2014
Adrenomedullin (ADM) is a peptide hormone widely expressed in different tissues, especially in the vasculature. Apart from its vasodilatatory and hypotensive effect, it plays multiple roles in the regulation of hormonal secretion, glucose metabolism and inflammatory response.
Cheung, TT, Tang, F, WONG, HK, Cheung, BMY   +3 more
openaire   +4 more sources

Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies: does utility depend on risk thresholds for treatment? [PDF]

, 2016
We tested the predictive ability of cardiac biomarkers N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T, and midregional pro adrenomedullin for cardiovascular disease (CVD) events using the British Regional Heart Study ...
Hart, Carole, McConnachie, Alex, Murray, Heather, Papacosta, Olia, Preiss, David, Ramsay, Sheena, Sattar, Naveed, Upton, Mark, Wannamethee, Goya, Watt, Graham, Welsh, Paul, Whincup, Peter   +11 more
core   +1 more source

An RNA vaccine against adrenomedullin reduces angiogenesis and tumor burden in a syngeneic metastatic melanoma mouse model

Frontiers in Immunology
IntroductionAdrenomedullin (AM) is an autocrine/paracrine growth factor as well as a crucial regulator of angiogenesis and immune response. AM is overexpressed by most solid tumors, which makes it a good target for anti-tumor therapy.MethodsIn this study,
Srdan Tadic, Laura Ochoa-Callejero, Judit Narro-Íñiguez, Josune García-Sanmartín, Alfredo Martínez   +4 more
doaj   +1 more source

Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese [PDF]

, 2011
Introduction: Liver enzymes are elevated in cardiometabolic diseases, particularly when there is non-alcoholic fatty liver disease. We therefore investigated if hypertension is associated with elevated levels of alkaline phosphatase (ALP), alanine ...
Cherny, SS, Cheung, BMY, Lam, KSL, Lam, TH, Ong, KL, Sham, PC, Tso, AWK   +6 more
core  

protection by adrenomedullin [PDF]

, 2014
Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide
Gruber, Achim Dieter, Hellwig, Katherina, Hippenstiel, Stefan, Kershaw, Olivia, Kummer, Wolfgang, Menger, Michael D., Müller-Redetzky, Holger C, Paddenberg, Renate, Pfeil, Uwe, Suttorp, Norbert, Tschernig, Thomas, Weissmann, Norbert, Will, Daniel, Witzenrath, Martin   +13 more
core   +1 more source