Results 81 to 90 of about 11,146 (212)

Adrenomedullin and the microvasculature

, 2002
The peptide adrenomedullin shows a remarkable range of effects on the vasculature that include vasodilatation, regulation of vascular smooth muscle cell proliferation, inhibition of endothelial apoptosis and promotion of angiogenesis.
Hague, Stephen, Smith, David M., Nikitenko, Leonid L., Wilson, Caroline R., Bicknell, Roy, Rees, Margaret C.P.   +5 more
core   +1 more source

An RNA vaccine against adrenomedullin reduces angiogenesis and tumor burden in a syngeneic metastatic melanoma mouse model

Frontiers in Immunology
IntroductionAdrenomedullin (AM) is an autocrine/paracrine growth factor as well as a crucial regulator of angiogenesis and immune response. AM is overexpressed by most solid tumors, which makes it a good target for anti-tumor therapy.MethodsIn this study,
Srdan Tadic, Laura Ochoa-Callejero, Judit Narro-Íñiguez, Josune García-Sanmartín, Alfredo Martínez   +4 more
doaj   +1 more source

Plasma adrenomedullin concentrations in patients with adrenal pheochromocytoma

, 2001
BACKGROUND: The hypotensive peptide adrenomedullin was first isolated in extracts of human pheochromocytoma. There is, however, no information available on the behaviour of circulating adrenomedullin or on the correlation with catecholamines in patients ...
E. Marinoni, E. D'Erasmo, E. M. Marinoni, D'ERASMO, Emilio, R. Di Iorio, S. Cerci, R. Massa, P. Alò, ALO', Piero Luigi, G. De Toma, MASSA, Rita, C. Caliumi, C. Letìzia, DIACINTI, Daniele, DE TOMA, Giorgio, R. D. Loria, LETIZIA, Claudio, D. Diacinti   +17 more
core   +1 more source

High Serum Adrenomedullin and Mid-Regional Pro-Atrial Natriuretic Peptide Concentrations in Early Pregnancy Predict the Development of Gestational Hypertension

Diagnostics
Objectives: Adrenomedullin (AM) and natriuretic peptide levels are elevated in pre-eclampsia. The aim of the present study was to determine AM and natriuretic peptide concentrations before 20 weeks of pregnancy in women who later developed gestational ...
Aleksandra Jagodzinska, Agnieszka Wsol, Agata Gondek, Agnieszka Cudnoch-Jedrzejewska   +3 more
doaj   +1 more source

Mechanisms of Adrenomedullin-Induced Dilatation of Cerebral Arterioles

, 1997
Background and Purpose Adrenomedullin is a recently discovered vasoactive peptide that is structurally related to calcitonin gene–related peptide (CGRP). Adrenomedullin is produced by vascular endothelium and smooth muscle and is
Roberto Paterno, Markus G. Lang, Frank M. Faraci, Donald D. Heistad   +3 more
core   +1 more source

Safety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial

Drug Design, Development and Therapy, 2020
Toshihiro Kita,1 Yoshikazu Kaji,2 Kazuo Kitamura1 1Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; 2Souseikai Hakata Clinic, Fukuoka, JapanCorrespondence ...
Kita T, Kaji Y, Kitamura K
doaj  

Protective Effects of Adrenomedullin on Rat Cerebral Tissue After Transient Bilateral Common Carotid Artery Occlusion and Reperfusion

Brazilian Journal of Cardiovascular Surgery
Objective: We aimed to investigate the protective effect of adrenomedullin (ADM) on cerebral tissue of rats with cerebral ischemia/reperfusion (I/R) injury. Methods: Thirty-two Wistar rats were randomized into four groups (n=8).
Mehmet Kirisci, Hakan Gunes, Aydemir Kocarslan, Tuba Ozcan Metin, Duygun Altintas Aykan, Muhammed Seyithanoglu, Adem Doganer, Gulsen Bayrak, Ekrem Aksu   +8 more
doaj   +1 more source

The role of adrenomedullin [PDF]

American Journal of Hypertension, 1999
C J, Charles, J G, Lainchbury, L K, Lewis, M T, Rademaker, A M, Richards, T G, Yandle, M G, Nicholls   +6 more
openaire   +2 more sources

Treatment of bone disorders with adrenomedullin

, 1999
A method for promoting bone growth in a patient (e.g., a mammal such as a human) said method including the step of administering a therapeutically effective amount of adrenomedullin or an adrenomedullin agonist to said ...
Coy, D H, Reid, Ian R, Cornish, Jill, Cooper, Garth   +3 more
core   +2 more sources

Effects of Adrenomedullin on Atrial Electrophysiology and Pulmonary Vein Arrhythmogenesis

, 2022
Adrenomedullin, a peptide with vasodilatory, natriuretic, and diuretic effects, may be a novel agent for treating heart failure. Heart failure is associated with an increased risk of atrial fibrillation (AF), but the effects of adrenomedullin on atrial ...
Yung-Kuo Lin, Shih-Ann Chen, Satoshi Higa, Higa, Satoshi, Chye-Gen Chin, Ahmed Moustafa Elimam, Hsieh, Ming-Hsiung, Chen, Yi-Jen, Chen, Yao-Chang, Lin, Fong-Jhih, Fong-Jhih Lin, Elimam, Ahmed Moustafa, Ming-Hsiung Hsieh, Lu, Yen-Yu, Yi-Jen Chen, Yen-Yu Lu, Chin, Chye-Gen, Yao-Chang Chen, Lin, Yung-Kuo, Chen, Shih-Ann   +19 more
core   +1 more source