Results 191 to 200 of about 2,492,374 (226)

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations

Allergy, EarlyView.
Little is known about the factors driving AIT prescription in clinical practice, including the level of personalization from patient to patient. Patient‐centred factors theoretically would favour SLIT prescription. Doctors’ knowledge, training, and country influence the final decision on the route.
Carmen Vidal, Davide P. Caimmi, Pablo Rodriguez del Rio, Óscar Lado‐Baleato, Francisco Gude, Pilar Rico‐Nieto, Thomas B. Casale, Jorge A. Aguilar, Maryam Ali Al‐Nesf, Fatima Ashkanani, Adeeb Bulkhi, Juan C. Cardet, Claudia Almendarez, Silvia Caimmi, Iván Cherrez, Enza D’Auria, Stephanie Dramburg, Motohiro Ebisawa, Naoko Fusayasu, Maximiliano Gomez, Sandra Gonzalez‐Diaz, Carla Irani, Andrey Kamaev, Connie Katelaris, Narinder Kaur, Oksana KurBacheva, José I. Larco, Désirée Larenas‐Linnemann, Margaret Li, Olga Patricia Monge‐Ortega, Pablo Moreno, Oliver Pfaar, Cesar F. Pozo‐Beltrán, Marta E. Rubio, Jorge Sanchez, Giovanni Sedo, Silvia Uriarte, Lin Yang, Hao Chen, Rongfei Zhu, Pascal Demoly, Moises A. Calderon, on behalf of the CHOICE‐Global Survey Team   +42 more
wiley   +1 more source

Occupational exposures and asthma-COPD overlap in a clinical cohort of adult-onset asthma. [PDF]

ERJ Open Res, 2019
Tommola M, Ilmarinen P, Tuomisto LE, Lehtimäki L, Kankaanranta H.   +4 more
europepmc   +1 more source

Maternal Perinatal Gut Microbiome Is Shaped by Traditional Farming Lifestyle and Associated With Early Childhood Atopic Disease

Allergy, EarlyView.
We assessed whether the maternal perinatal gut microbiome and serum SCFA and cord blood SCFA differ between traditional farming and urban dyads. Women following a farming lifestyle had increased microbial diversity, several differentially abundant bacterial species and functional pathways, and increased circulating SCFA. Overall maternal gut microbiome
Erin C. Davis, Courtney M. Jackson, Nichole S. Diaz, Jazmine Susana, Ashley Nelson, Richard Insel, Antti E. Seppo, Kirsi M. Järvinen   +7 more
wiley   +1 more source

Maternal Prebiotic Supplementation Modifies Associations Between Intrapartum Antibiotics and Infant Allergy

Allergy, EarlyView.
This study examined whether antibiotic use altered the risk of infant allergic disease within a maternal prebiotics supplementation trial. Intrapartum antibiotics were maternal antibiotics administered during childbirth, from the onset of labour or induction until 1‐h before delivery.
Summer V. M. Walker, Thomas R. Sullivan, Rachelle A. Pretorius, Nina D'Vaz, Johnny Lo, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Claus T. Christophersen, Debra J. Palmer   +10 more
wiley   +1 more source

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. [PDF]

Am J Hum Genet, 2019
Ferreira MAR, Mathur R, Vonk JM, Szwajda A, Brumpton B, Granell R, Brew BK, Ullemar V, Lu Y, Jiang Y, 23andMe Research Team, eQTLGen Consortium, BIOS Consortium, Magnusson PKE, Karlsson R, Hinds DA, Paternoster L, Koppelman GH, Almqvist C.   +18 more
europepmc   +1 more source

Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double‐Blind Randomised Placebo‐Controlled Trial

Allergy, EarlyView.
This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić, Stephan C. Flory, Claudia C. V. Lang, Emma C. Widmer, Alexandra Chabot, Johannes M. Schmid, Tobias Andermatt, David Melillo, Bjarke Hviid‐Vyff, Maibritt Mardahl, Peter Schmid‐Grendelmeier, Thomas M. Kündig, Hans Jürgen Hoffmann, Pål Johansen   +13 more
wiley   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source