Results 51 to 60 of about 2,492,374 (226)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk

Scientific Reports
Investigation of in utero, tissue-specific molecular pathways contributing to prenatal programming of childhood-onset asthma is needed to develop effective, targeted prevention strategies.
Elizabeth A. Jasper, Christopher G. McKennan, Emma E. Thompson, Nathan Schoettler, Tebeb Gebretsadik, Jacklyn N. Hellwege, Todd L. Edwards, Carole Ober, Digna R. Velez Edwards, Tina V. Hartert, Brittney M. Snyder   +10 more
doaj   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Effects of short-term smoking on lung function and airway hyper-responsiveness in young patients with untreated intermittent adult-onset asthma: retrospective cross-sectional study at a primary–tertiary care hospital in Japan

BMJ Open, 2019
ObjectiveIn daily clinical practice, smokers with asthma and with intermittent disease severity are frequently encountered. The effects of short-term smoking on lung function or disease presentation in younger patients with intermittent adult-onset ...
Kentaro Watai, Kiyoshi Sekiya, Hiroaki Hayashi, Yuma Fukutomi, Masami Taniguchi   +4 more
doaj   +1 more source

Age at asthma diagnosis and onset of symptoms among adults with allergic and non-allergic asthma

European Clinical Respiratory Journal, 2023
Background Childhood-onset allergic asthma is the best-known phenotype of asthma. Adult-onset asthma, also an important entity, is instead often shown to be more non-allergic.
Johanna Pakkasela, Petri Salmela, Pekka Juntunen, Jussi Karjalainen, Lauri Lehtimäki   +4 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort. [PDF]

PLoS ONE, 2013
BACKGROUND: We have previously identified four distinct groups of asthma patients in KOREAN cohorts using cluster analysis: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D) late-onset mild asthma.
So Young Park, Seunghee Baek, Sujeong Kim, Sun-Young Yoon, Hyouk-Soo Kwon, Yoon-Seok Chang, You Sook Cho, An-Soo Jang, Jung Won Park, Dong-Ho Nahm, Ho-Joo Yoon, Sang-Heon Cho, Young-Joo Cho, ByoungWhui Choi, Hee-Bom Moon, Tae-Bum Kim, COREA Study Group   +16 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

Risk factors for asthma exacerbations

Journal of Allergy and Clinical Immunology: Global
Background: The Global Initiative for Asthma (GINA) advises evaluation of risk factors for exacerbations. Patients with adult-onset asthma often have a problematic disease presentation with comorbidities.
Lauri Nordman, MD, Iida Vähätalo, PhD, Leena E. Tuomisto, MD, PhD, Onni Niemelä, MD, PhD, Minna Tommola, MD, PhD, Lauri Lehtimäki, MD, PhD, Pinja Ilmarinen, PhD, Hannu Kankaanranta, MD, PhD   +7 more
doaj   +1 more source