Results 81 to 90 of about 8,422,390 (331)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

青銀世代之數位遊戲使用認知與趨避衝突：語意聯想測驗之內容分析 Cognitive Differences and ApproachAvoidance Conflict in Digital Gaming Across Generations: Content Analysis of Taiwanese Individuals’ Responses on the Word Association Test

Journal of Research in Education Sciences
青銀世代對數位遊戲的使用動機具差異性，而數位遊戲的開發或設計往往無法為所有年齡層量身定做，例如長者對於規則太複雜、時間太緊湊的遊戲設計有負面的認知，但年輕人反而追求遊戲的效率。此外，過去探討不同世代數位遊戲設計及功能評估的研究，大多為受試者自陳、觀察和訪談方法蒐集主動意識層面的資料，較少透過語意聯想這類的結果探究。 據此，本研究欲以數位遊戲認知的語意聯想測驗（Word Association Test, WAT）蒐集多元的資料以探討世代間之異同。本研究以便利取樣招募178位不同年齡層的對象 ...
劉智淇 Chih-Chi Liu, 王雅鈴 Ya-Ling Wang   +1 more
doaj   +1 more source

Who moved my old cheese? Implications of COVID 19 to teaching and learning in Southern Africa

Journal of Teaching and Learning with Technology, 2021
This reflective essay seeks to share the authors’ thoughts and feelings on the impact of COVID 19 on the general teaching and learning strategies, theories and practices in the small kingdom of Eswatini in Southern Africa. Coming from varying backgrounds
Selloane Pitikoe, Karen Ferreira-Meyers, Sithulisiwe Bhebhe, Sithulisiwe Bhebhe, Nompumelelo Dlamini-Zwane   +4 more
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

從前瞻因應理論觀點探討翻轉教學策略應用 於退休準備課程在不同需求程度上之 教學成效 Exploring the Application of Flipped Teaching Strategies in Retirement Preparation Courses: An Analysis of Educational Effectiveness From the Perspective of Proactive Coping Theory Across Different Levels of Need

Journal of Research in Education Sciences
隨著臺灣即將進入超高齡社會，如何讓屆退民眾預先做好退休準備、確保退休生活品質，是當前臺灣高齡社會一項重要課題。本研究目的在以退休前10年的公教人員為研究對象，透過翻轉教學實驗瞭解學習需求與實際學習效果的差距，再藉由退休準備教育課程需求現況調查，瞭解不同需求課程實施翻轉教學策略的成效，進而調整出適合屆退族群的退休課程與教學策略，以培養其充足的退休知識與應用能力，做好前瞻因應的退休準備。本研究採用問卷調查法進行需求調查，研究設計採分層隨機抽樣，研究工具「臺灣退休準備教育課程需求指標 ...
胡夢鯨 Menq-Jing Hwu, 施宇澤 Yu-Ze Shih, 劉霽瑈 Ji-Rou Liu, 陳雅雯 Ya-Wen Chen   +3 more
doaj   +1 more source

A paired curriculum for surgical faculty and residents on adult education. [PDF]

Laryngoscope Investig Otolaryngol, 2023
Chen JX, Gray ST.
europepmc   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Adult education and entrepreneurship: getting young adults involved. [PDF]

J Innov Entrep, 2023
Biney IK.
europepmc   +1 more source

Adult Education in Practice [PDF]

, 1934
W. B. B.
openalex   +1 more source