Results 81 to 90 of about 8,578,623 (351)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
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Theories in Adult Learning and Education [PDF]
, 2011 The graduate student guide in adult education explores theories of adult learning and adult education participation. It provides a frame of reference for understanding the development of a rapidly evolving field and for enhancing knowledge and competencies in this professional domain.
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The Role of the Educator in Adult Education
Journal of Education and Learning (EduLearn), 2015 The educator in adult education according to the theory of Andragogy, social change and transformative learning is to work towards achieving positive change by coordinating the learning procedure in a way that enables the learner to overcome certain false believes he has due to social conditioning, his working environment and the way in which he has ...
Georgios Besas +3 more
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Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
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Who moved my old cheese? Implications of COVID 19 to teaching and learning in Southern Africa
Journal of Teaching and Learning with Technology, 2021 This reflective essay seeks to share the authors’ thoughts and feelings on the impact of COVID 19 on the general teaching and learning strategies, theories and practices in the small kingdom of Eswatini in Southern Africa. Coming from varying backgrounds
Selloane Pitikoe +4 more
doaj
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
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Journal of Research in Education Sciences隨著臺灣即將進入超高齡社會，如何讓屆退民眾預先做好退休準備、確保退休生活品質，是當前臺灣高齡社會一項重要課題。本研究目的在以退休前10年的公教人員為研究對象，透過翻轉教學實驗瞭解學習需求與實際學習效果的差距，再藉由退休準備教育課程需求現況調查，瞭解不同需求課程實施翻轉教學策略的成效，進而調整出適合屆退族群的退休課程與教學策略，以培養其充足的退休知識與應用能力，做好前瞻因應的退休準備。本研究採用問卷調查法進行需求調查，研究設計採分層隨機抽樣，研究工具「臺灣退休準備教育課程需求指標 ...
胡夢鯨 Menq-Jing Hwu +3 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
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Journal of Research in Education Sciences青銀世代對數位遊戲的使用動機具差異性，而數位遊戲的開發或設計往往無法為所有年齡層量身定做，例如長者對於規則太複雜、時間太緊湊的遊戲設計有負面的認知，但年輕人反而追求遊戲的效率。此外，過去探討不同世代數位遊戲設計及功能評估的研究，大多為受試者自陳、觀察和訪談方法蒐集主動意識層面的資料，較少透過語意聯想這類的結果探究。 據此，本研究欲以數位遊戲認知的語意聯想測驗（Word Association Test, WAT）蒐集多元的資料以探討世代間之異同。本研究以便利取樣招募178位不同年齡層的對象 ...
劉智淇 Chih-Chi Liu +1 more
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A paired curriculum for surgical faculty and residents on adult education. [PDF]
Laryngoscope Investig Otolaryngol, 2023 Chen JX, Gray ST.
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