Results 81 to 90 of about 15,097 (214)

[Leydig cell, Sertoli cell and adult granulosa cell tumors].

Der Pathologe, 2017
According to the World Health Organization (WHO) classification Leydig cell tumors, Sertoli cell tumors and granulosa cell tumors of the testes belong to the group of sex cord-stromal tumors. These tumors most frequently occur sporadically but in rare cases can be associated with syndromes. These tumor entities show characteristic morphological changes,
Bremmer, Felix, Schweyer, Stefan
openaire   +2 more sources

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study [PDF]

, 2014
Peer ...
Andersson, Noora Karoliina, Anttonen, Mikko, Butzow, Ralf, Färkkilä, Anniina, Heikinheimo, Markku, Leminen, Arto, Unkila-Kallio, Leila   +6 more
core   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Adult Granulosa Cell Tumor Associated with Endometrial Carcinoma

Journal of South Asian Federation of Obstetrics and Gynaecology, 2016
ABSTRACT Adult granulosa cell tumors account for approximately 1 and 2% of all ovarian tumors and 95% of all granulosa cell tumors. They occur more often in postmenopausal than in premenopausal women, with a peak incidence between 50 and 55 years of age. They are the most common estrogenic ovarian tumors diagnosed clinically.
Archana Baser, Alia K Zaidi, Nikita Sanghvi   +2 more
openaire   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature

Journal of Ovarian Research, 2018
Background Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 ...
Yuki Inada, Go Nakai, Kazuhiro Yamamoto, Takashi Yamada, Yoshinobu Hirose, Yoshito Terai, Masahide Ohmichi, Yoshifumi Narumi   +7 more
doaj   +1 more source

Loss and reappearance of gap junctions in regenerating liver [PDF]

, 1978
Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered.
Revel, J.-P., Yee, A. G.
core   +2 more sources

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors [PDF]

Endocrine-Related Cancer, 2014
The Hippo signaling pathway has been implicated as a conserved regulator of organ size in bothDrosophilaand mammals. Yes-associated protein (YAP), the central component of the Hippo signaling cascade, functions as an oncogene in several malignancies. Ovarian granulosa cell tumors (GCT) are characterized by enlargement of the ovary, excess production of
David, Fu, Xiangmin, Lv, Guohua, Hua, Chunbo, He, Jixin, Dong, Subodh M, Lele, David Wan-Cheng, Li, Qiongli, Zhai, John S, Davis, Cheng, Wang   +9 more
openaire   +2 more sources

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source