Results 101 to 110 of about 7,043,555 (280)

Effect of Growth Hormone (GH) on Fasting and Postprandial Metabolism in GH Deficiency

, 2010
Hypopituitarism with adult-onset growth hormone deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to premature and progressive atherosclerosis. An underlying cause of atherosclerosis is increased insulin resistance.
Trepp, R, E. Christ, Diem, P, Christ, E R, C. Stettler, P. Diem, R. Trepp, Stettler, C   +7 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Peripheral growth hormone induces cell proliferation in the intact adult rat brain

, 2010
Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats.
Lind, Johan,, Kuhn, Hans-Georg,, Åberg, N David,, Isgaard, Jörgen,   +3 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Significance of Using Questionnaire «Quality of Life Assessment in Adults with Growth Hormone Deficiency» in Patients with Non-functioning Pituitary Adenomas and Various Tumors of Chiasmosellar Area in Pre and Postoperative Period

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The authors surveyed 136 adult patients with growth hormone deficiency (GHD) of various origins (pituitary tumors and IHD — a comparison group). Study based on GHD questionnaire QoL-AGHDA quality of life of 136 patients revealed that in all groups the ...
Yu.M. Urmanova, M.Yu. Shakirova, D.A. Aliyeva   +2 more
doaj   +1 more source

Ocular findings in adult subjects with an inactivating mutation in GH releasing hormone receptor gene

, 2017
Objective: Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are necessary for a mature eyeball, needed for adequate vision.
Oliveira-Santos, A. A., Hellström, Ann,, Aguiar-Oliveira, M. H., Salvatoric, R., Faro, A. C. N., Oliveira, F. T., Oliveira, C. R. P., Valenca, E. H. O., Pereira-Gurgel, V. M., Oliveira-Neto, L. A., Campos, V. C., Melo, G. B., Pereira, F. A.   +12 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Adult Growth Hormone Deficiency

Journal of the Royal College of Physicians of London, 1998
Connie B. Newman, David L. Kleinberg
openaire   +3 more sources