Results 121 to 130 of about 7,349,585 (245)

Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?

, 2008
Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it ...
Elizabeth C Hersch, George R Merriam
core  

Efficacy and safety of once-weekly lonapegsomatropin in adults with growth hormone deficiency : foresiGHt trial results [PDF]

Adult growth hormone (GH) deficiency (GHD) is characterized by metabolic abnormalities caused by insufficient GH production. Lonapegsomatropin, a prodrug administered once weekly, was designed to provide sustained release of unmodified somatropin to ...
Biller, Beverly MK, Pico, Antonio, Fleseriu, Maria, Doknic, Mirjana, Gilis-Januszewska, Aleksandra, Garcia, Jose M., Yuen, Kevin C J, Huang, Eric, Silverstein, Julie M., Shu, Aimee D., Isidori, Andrea M, Garcia, Jose M, Kang, Jennifer, Komirenko, Allison S., Raverot, Gerald, Biller, Beverly M. K., Silverstein, Julie M, Biller, Beverly M K, Shu, Aimee D, Yuen, Kevin C. J., Domrzalski, Laurie, Fukuoka, Hidenori, Komirenko, Allison S, Pico, Antonio Miguel, Beckert, Michael, Isidori, Andrea M., Bancos, Irina, Takahashi, Yutaka   +27 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Growth hormone deficiency: strategies and indications to continue growth hormone therapy in transition from adolescence to adult life

, 2003
The most common practice in children with growth hormone (GH) deficiency is to discontinue GH treatment in adolescence after attainment of final height.
Johannsson, Gudmundur,, Leong, Gary M
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The role of growth hormone replacement in a growth hormone deficient patient with underlying cardiomyopathy and severe congestive heart failure

, 2005
It has been reported that-growth hormone (GH) deficiency induced cardiomyopathy responds to growth hormone replacement therapy. We describe the case of a middle-aged male with cardiomyopathic heart failure and growth hormone deficiency of the adult ...
Meyers, DE, Seaton, DM, Cuneo, RC, Galbraith, AJ, Maddicks-Law, J   +4 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

The Diagnosis of Growth Hormone Deficiency in Adults

Journal of Clinical Endocrinology & Metabolism, 1997
ANDERSEN M., HANGAARD J., HAGEN C., AIMARETTI G., GHIGO, Ezio   +4 more
openaire   +6 more sources

Exercise-induced Growth Hormone Secretion in the Assessment of Growth Hormone Deficiency in Adult Individuals

, 2011
The role of exercise testing in the assessment of GH deficiency (GHD) in adult patients is currently unclear. This study aimed at evaluating the diagnostic value of exercise-induced GH levels in the detection of severe GHD in adult ...
Allemann, Sabin, Zueger, Thomas, Christ, Emanuel R, Emanuel R Christ, Christoph Stettler, Sabin Alleman, Thomas Zueger, Stettler, Christoph, Zueger T, Alleman S, Christ ER, Christ, Emanuel, Stettler C, Züger, Thomas Johannes   +13 more
core   +1 more source