Results 141 to 150 of about 152,745 (292)

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Effects of 18 Months of Growth Hormone Replacement Therapy on Bone Mineral Density in Patients with Adult Growth Hormone Deficiency: A Retrospective Study. [PDF]

Int J Endocrinol, 2023
Shen YY, Ma JN, Ren ZY, Liu J, Zhou XY, Xie XR, Ren W.   +6 more
europepmc   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Behavioral Therapy Ameliorates Severe Obesity With Low Levels of Plasma GH and IGF‐1: A Case Report

Clinical Case Reports
We encountered a patient with a body mass index of 50.7 kg/m2. Behavioral therapy was effective for preventing progression of health disturbance in this case.
Go Yoshimichi
doaj   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Frontiers in Endocrinology
Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH ...
Kevin C. J. Yuen, Rikke Hjortebjerg, Rikke Hjortebjerg, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, David R. Clemmons, Jan Frystyk, Jan Frystyk   +9 more
doaj   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile. [PDF]

Pituitary, 2022
Ratku B, Sebestyén V, Erdei A, Nagy EV, Szabó Z, Somodi S.   +5 more
europepmc   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

Editorial: New Insights and Controversies in Diagnosis and Treatment of Adult Growth Hormone Deficiency. [PDF]

Front Endocrinol (Lausanne), 2021
Mancini A, Arosio M, Kreitschmann-Andermahr I, Persani L.   +3 more
europepmc   +1 more source

Body composition, IGF1 status, and physical functionality in nonagenarians: implications for osteosarcopenia [PDF]

, 2018
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in ...
Cherry, Ke, Jazwinski, Sm, Kim, S, Myers, L, Poggiogalle, E, Ravussin, E., Su, Lj, Welsh, Da   +7 more
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