Results 31 to 40 of about 68,269 (245)
A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency
Endocrine Connections, 2017 TransCon growth hormone is a sustained-release human growth hormone prodrug under development in which unmodified growth hormone is transiently linked to a carrier molecule.
Charlotte Höybye +8 more
doaj +1 more source
Early versus late initiation of GH replacement in adult-onset hypopituitarism
Endocrine Connections, 2020 Introduction: Adult-onset growth hormone deficiency (AGHD) is usually the la st deficiency to be substituted in hypopituitarism. In children wit h documented GH deficiency, treatment without delay is crucial for achieving opt imal effects on growth and ...
Mark R Postma +2 more
doaj +1 more source
Ожирение и метаболизм, 2011 Adult-onset growth hormone deficiency (GHD) remains one of the issues in clinical endocrinology. In this article, which is addressed to practitioners, physiology of growth hormone in adults is reviewed along with etiology and diagnostic criteria of this ...
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian +13 more
wiley +1 more source
Growth hormone deficiency and replacement in adults [PDF]
BMJ, 1996 Evidence gathered over the past 10 years indicates that growth hormone deficiency in adults is associated with adverse changes in body composition, lipid profile, insulin status, physical performance, bone mineral density, and quality of life. Furthermore, randomised placebo controlled studies indicate that, to varying degrees, growth hormone ...
openaire +2 more sources
Misperception of Body Weight After Childhood Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle +8 more
wiley +1 more source
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Frontiers in Endocrinology, 2017 BackgroundHypopituitarism as a result of PROP1 (prophet of PIT1) mutation represents the most common genetic cause of combined deficiency of pituitary hormones and due to growth retardation it is typically diagnosed in childhood.Case descriptionWe ...
Ludmila Brunerova +5 more
doaj +1 more source
GROWTH HORMONE THERAPY FOR ADULT GROWTH HORMONE DEFICIENCY
International Journal of Clinical Practice, 1998 SUMMARYGrowth hormone deficiency in adult life is associated with a number of adverse biological changes which include osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Most of these changes can be reversed by growth hormone replacement therapy,
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source