Results 31 to 40 of about 7,043,555 (280)

A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency [PDF]

, 2012
Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD)
Hiedl, Stefan, Duran-Prado, Mario, Lohse, Peter, Roeb, Julia, Rhodes, Simon J., Malik, Raleigh E., Bechtold-Dalla Pozza, Susanne, Park, Soyoung   +7 more
core   +1 more source

Idiopathic Male Osteoporosis and Growth Hormone Deficiency

Endocrinology Research and Practice, 2022
Growth hormone is essential in normal bone growth and maintenance of bone metabolism. In the setting of childhood onset growth hormone deficiency, osteoporosi s is inevitable without replacement therapy. Growth hormone demonstrates its function over bone
Gürcan Kısakol, Gökhan Özgen
doaj   +2 more sources

Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report

Journal of Medical Case Reports, 2010
Introduction Adult Growth hormone Deficiency is a well known phenomenon effecting both males and females. Adult Growth Hormone Deficiency is marked by a number of neuropsychiatric, cognitive performance, cardiac, metabolic, muscular, and bone symptoms ...
Madigan Margaret, Chen Thomas JH, Yeldandi Swetha, Damle Uma J, Bowirrat Abdalla, Braverman Eric R, Kerner Mallory, Huang Stanley X, Savarimuthu Stella, Blum Kenneth   +9 more
doaj   +1 more source

Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial [PDF]

Arquivos de Neuro-Psiquiatria, 1999
BACKGROUND: Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during stress, depressive symptoms) that may cause deleterious effects on quality of life, and may be positively influenced by
CLÁUDIO DE NOVAES SOARES, NINA ROSA MUSOLINO, MALEBRANCHE CUNHA NETO, MARIA ADELAIDE CAIRES, MARIA CRISTINA ROSENTHAL, CANDIDA PIRES CAMARGO, MARCELLO D. BRONSTEIN   +6 more
doaj   +1 more source

Growth hormone deficiency and the transition from pediatric to adult care

Jornal de Pediatria, 2021
Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH ...
Ana Beatriz Winter Tavares, Paulo Ferrez Collett-Solberg   +1 more
doaj   +1 more source

The influence of growth hormone deficiency on bone health and metabolism

, 2023
Growth hormone (GH) is a key peptide hormone in the regulation of bone metabolism, through its systemic and paracrine action mediated directly as well as by insulin-like growth factor-1 (IGF-1).
Jakub Wydra, Wojciech Zgliczyński, Arnika Wydra, Izabella Czajka-Oraniec   +3 more
core   +1 more source

Effects of long-term growth hormone therapy in a girl with Floating-Harbor syndrome [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2020
Floating-Harbor syndrome is a rare autosomal dominant disorder that presents with short stature, facial dysmorphism, significantly delayed bone age, skeletal abnormalities, speech and language problems, and intellectual disabilities.
Hyun Woo Son, Jeong Eun Lee, Seung Hwan Oh, Changwon Keum, Woo Yeong Chung   +4 more
doaj   +1 more source

A Novel Pathogenic IGSF1 Variant in a Patient with GH and TSH Deficiency Diagnosed by High IGF-I Values at Transition to Adult Care

JCRPE, 2023
IGSF1 deficiency is a rare X-linked condition characterized by central hypothyroidism and a wide variety of other clinical features with variable prevalence, including a delayed pubertal testosterone rise and growth spurt in the context of normal or ...
Aslı Derya Kardelen, Esin Karakılıç Özturan, Şükran Poyrazoğlu, Firdevs Baş, Serdar Ceylaner, Sjoerd D. Joustra, Jan M. Wit, Feyza Darendeliler   +7 more
doaj   +1 more source

Response to Growth Hormone Treatment in Isolated Growth Hormone Deficiency versus Multiple Pituitary Hormone Deficiency

, 2021
Background: Growth hormone (GH) therapy successfully increases height prognosis in children with GH deficiency (GHD); however, adult height data are still limited. Aim: This study investigated near-adult height (NAH) in patients with idiopathic GHD (i.e.
Darendeliler, Fatma Feyza, Lindberg, A., Wilton, P.   +2 more
core   +1 more source

Discontinuation of long-term growth hormone treatment in adults with growth hormone deficiency: a survey of UK practice

Endocrine Connections
Objective: We conducted a survey of UK endocrine clinicians between June 2022 and August 2022 to understand current practices regarding GH treatment discontinuation in adults with growth hormone deficiency.
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil Gittoes, Anne Topping, Niki Karavitaki   +5 more
doaj   +1 more source