Results 41 to 50 of about 7,043,555 (280)
A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency
Endocrine Connections, 2017 TransCon growth hormone is a sustained-release human growth hormone prodrug under development in which unmodified growth hormone is transiently linked to a carrier molecule.
Charlotte Höybye +8 more
doaj +1 more source
Ожирение и метаболизм, 2011 Adult-onset growth hormone deficiency (GHD) remains one of the issues in clinical endocrinology. In this article, which is addressed to practitioners, physiology of growth hormone in adults is reviewed along with etiology and diagnostic criteria of this ...
doaj +1 more source
Early versus late initiation of GH replacement in adult-onset hypopituitarism
Endocrine Connections, 2020 Introduction: Adult-onset growth hormone deficiency (AGHD) is usually the la st deficiency to be substituted in hypopituitarism. In children wit h documented GH deficiency, treatment without delay is crucial for achieving opt imal effects on growth and ...
Mark R Postma +2 more
doaj +1 more source
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Growth hormone deficiency and replacement in adults [PDF]
BMJ, 1996 Evidence gathered over the past 10 years indicates that growth hormone deficiency in adults is associated with adverse changes in body composition, lipid profile, insulin status, physical performance, bone mineral density, and quality of life. Furthermore, randomised placebo controlled studies indicate that, to varying degrees, growth hormone ...
openaire +2 more sources
Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency [PDF]
, 2004 Objective: To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD).Subjects: A total of 337 prepubertal GHD patients aged,10 years from the UK ...
Hindmarsh, PC, Dunger, DB, Cole, TJ
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
GROWTH HORMONE THERAPY FOR ADULT GROWTH HORMONE DEFICIENCY
International Journal of Clinical Practice, 1998 SUMMARYGrowth hormone deficiency in adult life is associated with a number of adverse biological changes which include osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Most of these changes can be reversed by growth hormone replacement therapy,
openaire +2 more sources
Genetics of growth hormone deficiency
, 2007 When a child is not following the normal, predicted growth curve, an evaluation for underlying illness and central nervous system abnormalities is required and appropriate consideration should be given to genetic defects causing growth hormone (GH ...
Mullis, Primus E
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens +6 more
wiley +1 more source