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Growth hormone treatment for growth hormone deficient adults [PDF]

Journal of Clinical Pharmacy and Therapeutics, 1996
Growth hormone (GH) deficiency in adults is now recognized as a clinical syndrome with characteristic signs and symptoms. Numerous trials with daily subcutaneous biosynthetic human growth hormone (hGH) have been conducted in this patient group. Generally, improvements in insulin-like growth factor levels, decreases in total fat mass and increases in ...
W, Clark, M J, Kendall
openaire   +2 more sources

Cushing disease due to a somatic USP8 mutation in a patient with evolving pituitary hormone deficiencies due to a germline GH1 splicing variant

Archives of Endocrinology and Metabolism, 2022
SUMMARY We present the unique case of an adult Brazilian woman with severe short stature due to growth hormone deficiency with a heterozygous G to T substitution in the donor splice site of intron 3 of the growth hormone 1 (GH1) gene (c.291+1G>T).
Julia Haddad Labello, Anna Flávia Figueredo Benedetti, Bruna Viscardi Azevedo, Alexander Augusto de Lima Jorge, Valter Angelo Sperling Cescato, Sergio Rosemberg, Fernando Pereira Frasseto, Ivo Jorge Prado Arnhold, Luciani Renata Silveira de Carvalho   +8 more
doaj   +1 more source

Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the growth hormone research society workshop on adult growth hormone deficiency [PDF]

, 1998
Based on the increasing body of evidence that adults with GH deficiency (somatotropin deficiency) have impaired health that improves with GH replacement, many countries have already approved the use of GH for replacement therapy in adults with GH ...
Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency, Clemmons, David   +1 more
core   +1 more source

The Effects of Growth Hormone Therapy on Echocardiographic Parameters in Growth Hormone Deficient (GDH) Patients

Endocrinology Research and Practice, 2022
Ideas about hormone replacement therapy in hypopituitarism have changed since the discovery of increased atheroscferotic process caused by growth hormone (GH) deficiency.The aim of this study is to see the effect of GH therapy on cardiac functions and ...
Füsun Hamulu, Ahmet Gökhan Özgen, Candeğer Yılmaz, Fırat Bayraktar, Cahide Soydaş, Filiz Özerkan   +5 more
doaj   +2 more sources

Adult growth hormone deficiency: academic extravagance or real clinical entity for the internist?

Italian Journal of Medicine, 2013
The Growth Hormone (GH) continues to act lifelong: it has been described, in fact, an Adult Growth Hormone Deficiency (AGHD) syndrome, involving several organs and functions, whose clinical aspects greatly improve with the administration of human ...
Giovanni Scanelli, Luca Catapano, Beatrice Traverso, Claudia Aimoni   +3 more
doaj   +1 more source

Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation [PDF]

, 2010
Study found that treatment with recombinant human growth hormone gave significantly greater benefits in stature for children with growth hormone deficiency (GHD), Turner syndrome, Prader–Willi syndrome, chronic renal insufficency, short stature homeobox ...
Bird, A., Baxter, L, Gospodarevskaya, E., K Welch, Cooper, Keith, L Baxter, Frampton, G. K., A Bird, Frampton, GK, Gospodarevskaya, Elena, Gospodarevskaya, E, Welch, K, Bryant, J, Takeda, A, Frampton, G.K., Cooper, K., GK Frampton, Takeda, Andrea, Bird, A, Bryant, J., J Bryant, K Cooper, Welch, Karen, Welch, K., Baxter, L., Takeda, A., Bryant, Jackie, A Takeda, E Gospodarevskaya, Cooper, K   +29 more
core   +1 more source

Effect of Growth Hormone (hGH) Replacement Therapy on Physical Work Capacity and Cardiac and Pulmonary Function in Patients with hGH Deficiency Acquired in Adulthood. [PDF]

, 1995
The effects of 6 months of replacement therapy with recombinant human GH (hGH) on physical work capacity and cardiac structure and function were investigated in 20 patients with hGH deficiency of adult onset in a double blind, placebo-controlled trial ...
Schopohl, Jochen, Nass, Ralf, Strasburger, Christian J., Klauss, Volker, Müller, Otto A., Huber, Rudolf M.   +5 more
core   +1 more source

The Treatment of Growth Hormone Deficiency in Adults [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2000
In analogy with other hormonal replacement therapy GH treatment should be commenced with a low starting dose, independent of body weight or body surface area. Hormonal replacement should mimic the normal physiology to minimize the risk of side effects in the life-long replacement of adults.
B A, Bengtsson, G, Johannsson, S M, Shalet, H, Simpson, P H, Sonken   +4 more
openaire   +2 more sources

Harmonization of growth hormone measurements with different immunoassays by data adjustment [PDF]

, 2011
Background: The aim of our study was to evaluate the between-assay variability of commercially available immunoassays for the measurement of human growth hormone (hGH).
Bidlingmaier, Martin, Oliver Blankenstein, Jürgen Kratzsch, Körner, Antje, Wieland Kiess, Anne Müller, Markus Scholz, Antje Körner, Thiery, Joachim, Martin Bidlingmaier, Müller, Anne, Scholz, Markus, Blankenstein, Oliver, Annegret Heider, Roland Pfäffle, Joachim Thiery, Heider, Annegret, Kratzsch, Jürgen, Gerhard Binder, Pfäffle, Roland, Binder, Gerhard, Kiess, Wieland   +21 more
core   +1 more source

Physician’ attitudes to growth hormone replacement therapy in adults following pituitary surgery: Results of an online survey

Avicenna Journal of Medicine, 2020
Objective: The aim of this study was to evaluate physician attitudes and practices in the management of adult growth hormone deficiency (GHD) following pituitary surgery. Materials and Methods: An online questionnaire survey was sent to a sample group of
Aishah Ekhzaimy, Salem A Beshyah, Khaled M Al-Dahmani, Mussa H AlMalki   +3 more
doaj   +1 more source