Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics [PDF]
Frontiers in Immunology, 2023 Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural circuits, thus benefiting the treatment of depression.
Shaoyi Fang +14 more
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What Is Adult Hippocampal Neurogenesis Good for? [PDF]
Front Neurosci, 2022 Adult hippocampal neurogenesis is a unique and exceptional process in the mammalian brain that in a lifelong and activity-dependent way generates new excitatory principal neurons. A comprehensive view on their function in greater contexts has now emerged,
Kempermann G.
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Adult hippocampal neurogenesis and its impairment in Alzheimer's disease. [PDF]
Zool Res, 2022 Adult neurogenesis is the creation of new neurons which integrate into the existing neural circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis (AHN) persists throughout life in mammals, including humans. These newborn
Kim TA, Syty MD, Wu K, Ge S.
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A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease [PDF]
Neural Regeneration Research, 2022 Several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus, a process named adult hippocampal neurogenesis, contribute to maintaining healthy ...
Maya A Hanspal, Sébastien Gillotin
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Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis. [PDF]
Brain Plast, 2022 The birth, maturation, and integration of new neurons in the adult hippocampus regulates specific learning and memory processes, responses to stress, and antidepressant treatment efficacy.
Guzzetta KE, Cryan JF, O'Leary OF.
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Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling
Frontiers in Cell and Developmental Biology, 2022 The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target for inducing adult hippocampal neurogenesis and antidepressant therapy.
Chong Gao +4 more
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The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis [PDF]
EMBO ReportsAdult neural stem cells (NSCs) in the hippocampal dentate gyrus continuously proliferate and generate new neurons throughout life. Although various functions of organelles are closely related to the regulation of adult neurogenesis, the role of ...
Naoya Murao +7 more
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Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Frontiers in Cell and Developmental Biology, 2020 Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate ...
Sebastian B. Arredondo +3 more
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Adult Hippocampal Neurogenesis: A Coming-of-Age Story [PDF]
Journal of Neuroscience, 2018 What has become standard textbook knowledge over the last decade was a hotly debated matter a decade earlier: the proposition that new neurons are generated in the adult mammalian CNS.
H. Georg Kuhn +2 more
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Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. [PDF]
Cell Stem Cell, 2023 Salta E +5 more
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