Results 181 to 190 of about 39,669 (209)

Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

Charline C, Frédéric C, Sébastien S, Thomas L, Kévin R, Jeanne E, Nicolas R, Marta V, Andreas S, Francesco P, Marlen K, Ruth B, Nicolas T.   +12 more
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Adult hippocampal neurogenesis in depression

Nature Neuroscience, 2007
The development of new treatments for depression is predicated upon identification of neural substrates and mechanisms that underlie its etiology and pathophysiology. The heterogeneity of depression indicates that its origin may lie in dysfunction of multiple brain regions.
Amar, Sahay, Rene, Hen
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Adult hippocampal neurogenesis and aging

European Archives of Psychiatry and Clinical Neuroscience, 2007
The demographic changes in the foreseeable future stress the need for research on successful cognitive aging. Advancing age constitutes a primary risk factor for disease of the central nervous system most notably neurodegenerative disorders. The hippocampus is one of the brain regions that is prominently affected by neurodegeneration and functional ...
Friederike, Klempin, Gerd, Kempermann
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CDK2 is Dispensable for Adult Hippocampal Neurogenesis

Cell Cycle, 2007
Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus.
Vandenbosch, Renaud, Borgs, Laurence, Beukelaers, Pierre, Foidart, Agnès, Nguyen, Laurent, Moonen, Gustave, Berthet, Cyril, Kaldis, Philipp, Gallo, Vittorio, Belachew, Shibeshih, Malgrange, Brigitte   +10 more
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Adult hippocampal neurogenesis and antidepressants effects

Current Opinion in Pharmacology, 2020
The hippocampus is particularly involved in cognitive processes and is a key regulator of stress responses and emotions. Therefore, the role of adult-born neurons in this region has become a crucial field of research in order to understand mood and stress disorders, such as major depression.
Barbara, Planchez, Alexandre, Surget, Catherine, Belzung   +2 more
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GABAergic Regulation of Adult Hippocampal Neurogenesis

Molecular Neurobiology, 2016
Adult hippocampal neurogenesis has been implicated in several brain functions, including learning and memory processes. It also plays an important role in the aetiology of anxiety disorders, depression and age-related deficits. The endogenous stem cell pool is also known to hold great potential for ameliorating the diseased or aged brain.
Sibbe, Mirjam, Kulik, Akos
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A developmental perspective on adult hippocampal neurogenesis

International Journal of Developmental Neuroscience, 2013
AbstractThe generation of new neurons from neural stem cells (NSCs) throughout adult life in the mammalian brain is a biological process that fascinates scientists for its uniqueness and restorative potential. In the dentate gyrus (DG) of the hippocampus NSCs are able to self‐renew and generate new granule cells and astrocytes through a complex and ...
Juan M, Encinas, Amanda, Sierra, Roberto, Valcárcel-Martín, Soraya, Martín-Suárez   +3 more
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Neurogenesis and Hippocampal Plasticity in Adult Brain

2012
Plasticity in the adult brain enables lifelong learning. The fundamental mechanism of adult neural plasticity is activity-dependent reorganization of pre-existing structure, in contrast to the widespread cellular proliferation and migration that occurs during development. Whereas adult hippocampal dentate gyrus continuously generates cohorts of neurons,
Yan, Gu, Stephen, Janoschka, Shaoyu, Ge
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