Results 41 to 50 of about 110,453 (370)
Role of adult hippocampal neurogenesis in the antidepressant actions of lactate
Molecular Psychiatry, 2021 In addition to its role as a neuronal energy substrate and signaling molecule involved in synaptic plasticity and memory consolidation, recent evidence shows that lactate produces antidepressant effects in animal models.
A. Carrard +6 more
semanticscholar +1 more source
D-serine increases adult hippocampal neurogenesis [PDF]
Frontiers in Neuroscience, 2013 Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes.
Sultan Sebastien +3 more
openaire +5 more sources
Role of adult hippocampal neurogenesis in stress resilience
Neurobiology of Stress, 2015 There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional and cognitive processes related to psychiatric disorders. Although many studies have investigated the effects of stress on adult hippocampal neurogenesis, most ...
Brunno R. Levone +2 more
doaj +1 more source
Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis
Frontiers in Cellular Neuroscience, 2018 In mammalian species, including humans, the hippocampal dentate gyrus (DG) is a primary region of adult neurogenesis. Aberrant adult hippocampal neurogenesis is associated with neurological pathologies.
Jennifer Stefani +10 more
doaj +1 more source
Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
Journal of Neuroscience, 2020 During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but
Irune Díaz-Aparicio +19 more
semanticscholar +1 more source
Depression and adult hippocampal neurogenesis
Folia Pharmacologica Japonica, 2010 現在，うつ病の治療薬はセロトニンやノルアドレナリンといったモノアミンを増加させる薬剤が中心として用いられているが，脳内の細胞外モノアミン濃度は抗うつ薬の投与数時間後には増加するのに対し，臨床における治療効果発現までには数週間の慢性投与が必要とされることもあり，抗うつ薬の治療発現メカニズムは未だ明らかとされていない．近年，成熟期の脳においても海馬歯状回といった特定領域において，神経幹・前駆細胞が存在し，神経細胞が新生されることが明らかにされている．この海馬における神経新生は，うつ病発症の危険因子とされるストレスによって抑制され，逆に抗うつ薬を慢性投与することによって促進される．さらに，海馬神経新生を阻害すると，行動薬理評価モデルにおける抗うつ薬の作用が消失するなどの報告から ...
Takahiro, Masuda +2 more
openaire +3 more sources
International Journal of Molecular Sciences, 2021 Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult neurogenesis, which this review discusses as one reason why psychiatric ...
J. Leschik, B. Lutz, A. Gentile
semanticscholar +1 more source
Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats [PDF]
, 2018 Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus.
Cacao, Eliedonna +2 more
core +3 more sources
Sirt6 alters adult hippocampal neurogenesis
PLOS ONE, 2017 Sirtuins are pleiotropic NAD+ dependent histone deacetylases involved in metabolism, DNA damage repair, inflammation and stress resistance. SIRT6, a member of the sirtuin family, regulates the process of normal aging and increases the lifespan of male mice over-expressing Sirt6 by 15%.
Eitan Okun +7 more
openaire +4 more sources
Interleukin-17 inhibits Adult Hippocampal Neurogenesis [PDF]
Scientific Reports, 2014 Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus.
Liu, Qiang +7 more
openaire +2 more sources