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Neurogenesis in the adult hippocampus
Hippocampus, 2006AbstractThe dentate gyrus (DG) contains one of the few neuronal populations in the mammalian brain that are generated throughout life. Research into the regulation and function of adult neurogenesis continues its rapid growth in popularity. With the researcher new to the field in mind, we review the processes that together constitute adult neurogenesis
Brian R, Christie, Heather A, Cameron
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Neurogenesis in the adult hippocampus
Cell and Tissue Research, 2007New neurons continue to be generated in two privileged areas of the adult brain: the dentate gyrus of the hippocampal formation and the olfactory bulb. Adult neurogenesis has been found in all mammals studied to date, including humans. The process of adult neurogenesis encompasses the proliferation of resident neural stem and progenitor cells and their
Dan, Ehninger, Gerd, Kempermann
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Signaling in Adult Neurogenesis
Annual Review of Cell and Developmental Biology, 2009The identification of neural stem cells (NSCs) and their contribution to continuous neurogenesis has shown that the hippocampus and olfactory bulb are plastic. Brain plasticity, achieved at the level of cell genesis, has an essential role in the maintenance of brain homeostasis.
Hoonkyo, Suh, Wei, Deng, Fred H, Gage
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Hippocampus, 2006
AbstractStress hormones have potent growth‐inhibiting effects on a variety of peripheral tissues. Consistent with this general function, stress has been shown to inhibit cell proliferation and, ultimately, neurogenesis in the hippocampus. This effect appears to be common across mammalian species, life stages, and most types of stressors.
Christian, Mirescu, Elizabeth, Gould
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AbstractStress hormones have potent growth‐inhibiting effects on a variety of peripheral tissues. Consistent with this general function, stress has been shown to inhibit cell proliferation and, ultimately, neurogenesis in the hippocampus. This effect appears to be common across mammalian species, life stages, and most types of stressors.
Christian, Mirescu, Elizabeth, Gould
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Science, 2019
Neurogenesis in adulthood has implications for sense of self, memory, and ...
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Neurogenesis in adulthood has implications for sense of self, memory, and ...
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Adult neurogenesis and neuroplasticity
Restorative Neurology and Neuroscience, 2006After cerebral strokes and traumatic brain injuries (TBIs), there is a striking amount of neurological recovery in the following months and years, despite often-permanent structural damage. Though the mechanisms underlying such recovery are not fully understood, properties of plasticity of the central nervous system (CNS), such as the reorganization of
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Adult neurogenesis in the hippocampus
Hippocampus, 2023Gerd Kempermann +2 more
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Developmental dysregulation of adult neurogenesis
European Journal of Neuroscience, 2011AbstractRather than a singular event that suddenly appears during adulthood, adult neurogenesis has long been recognized as the continuation of postnatal neurogenic activity. During the first postnatal weeks, significant cellular changes occur within and adjacent to germinal matrices of the subventricular zone and dentate gyrus. The majority of granule
H, Georg Kuhn, K, Blomgren
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Adult Neurogenesis and Neurodegenerative Disease
Regenerative Medicine, 2005Advances in stem cell biology of the adult brain and the discovery of adult neurogenesis have raised the hope that neurodegenerative disorders might ultimately become amenable to causal therapy. Stem cells contribute to cellular plasticity during the lifespan, and in some sense, brain development never ends.
Barbara, Steiner +2 more
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Hormones and adult neurogenesis in mammals
Expert Review of Endocrinology & Metabolism, 2007Initial studies on neural stem cell biology were performed mainly with embryonic stem cells, but exciting discoveries and advances in knowledge about tissue-specific stem cells have emerged in the last few years. This review focuses on stem and/or progenitor cells in the brain that drive adult neurogenesis in mammals. Neuronal precursor cells are found
Samantha J, Richardson +2 more
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