Results 231 to 240 of about 1,598,089 (284)

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

Photoperiodism, testosterone and adult neurogenesis in canaries (Serinus canaria). [PDF]

J Neuroendocrinol
Balthazart J.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The chemotherapy agent doxorubicin induces CNS expression of Ascl1, a regulator of adult neurogenesis and differentiation. [PDF]

Sci Rep
Ng CAS, Pedus M, Lee MF, Kromer LF, Mandelblatt J, Rebeck GW.   +5 more
europepmc   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Structural and functional neuroimaging of hippocampus to study adult neurogenesis in long COVID-19 patients with neuropsychiatric symptoms: a scoping review. [PDF]

PeerJ
Saikarthik J, Saraswathi I, Padhi BK, Shamim MA, Alzerwi N, Alarifi A, Gandhi AP.   +6 more
europepmc   +1 more source

Adult neurogenesis in the ventral hippocampus decreased among animal models of neurodevelopmental disorders. [PDF]

Front Neural Circuits
Sun L, Ohashi N, Mori T, Mizuno Y, Zang W, Guo Q, Kouyama-Suzuki E, Shirai Y, Tabuchi K.   +8 more
europepmc   +1 more source

Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome. [PDF]

PLoS One
Islam MR, Jackson B, Naomi MT, Schatz B, Tan N, Murdock M, Park DS, Amorim DR, Jiang X, Pineda SS, Adaikkan C, Fernandez Avalos V, Geigenmuller U, Firenze RM, Kellis M, Boyden ES, Tsai LH.   +16 more
europepmc   +1 more source