Results 91 to 100 of about 3,127,180 (269)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
METHODICAL ASPECTS REGARDING TRAINING FOR JUMPS′ TESTS AT ADVANCED LEVEL AT “LPS - CSŞ SUCEAVA” CLUB [PDF]
Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement, 2019 The paper aims at a detailed study of the layout of the main means used by the coaches in the advanced level groups. The study was conducted during one year of training starting in September 2017, the month in which we tested the initial level of ...
Cojocaru Daniela
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
APIC 2019 Meeting - Advanced Peripheral Interventions Course - Acute Stroke Intervention Course
Sakarya Tıp Dergisi, 2019 APIC 2019 Meeting - Advanced Peripheral Interventions Course - Acute Stroke Intervention ...
Apic 2019 Meeting - Advanced Peripheral İnterventions Course - Acute Stroke Intervention Course
doaj
Frontiers in ImmunologyIntroductionAnti-PD-1 immune checkpoint inhibitors have substantially changed melanoma management in both the adjuvant and advanced settings. This study aimed to estimate the percentage of stage III and IV melanoma patients exposed to different therapies
Miso Kim +45 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source