Results 61 to 70 of about 3,127,180 (269)

Head and neck cancer – emerging targeted therapies

Frontiers in Oncology
Systemic therapy remains the cornerstone of treatment for recurrent and metastatic (R/M) head and neck squamous cell cancers (HNSCC). However, there is a dearth of effective treatments beyond platinum combinations, anti-programmed death-1 (PD-1) agents ...
Yasser Abouelkheer, Aarti Bhatia
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Efficacy and safety of anlotinib for the treatment of advanced bone and soft tissue sarcomas: a systematic review and meta-analysis

Frontiers in Oncology
BackgroundSarcoma, a rare and highly heterogeneous malignant neoplasm originating from mesenchymal tissues, is broadly classified into bone sarcoma and soft tissue sarcoma depending on where they occur.
Zhipeng Li, Peng Fang, Shiwen Shen, Lei Zhang, Rui Xie, Chengjun Li   +5 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

IJCM_148A: Difference in unmet supportive care needs of patients and informal caregivers with advanced cancer, between developed and developing countries: A scoping review

Indian Journal of Community Medicine
Background: Cancer’s global impact is surging, burdening both developed and developing nations. Therapeutic advances extend life but heighten morbidity, highlighting unmet needs.
Madhu P Malar, Animesh Jain, Ramesh Holla, Rajath Rao, Mithun Rao, Jobinse Jose   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Use of the MNCD Classification to Monitor Clinical Stage and Response to Levodopa-Entacapone-Carbidopa Intestinal Gel Infusion in Advanced Parkinson’s Disease

Brain Sciences
Background and objective: Staging Parkinson’s disease (PD) with a novel simple classification called MNCD, based on four axes (Motor; Non-motor; Cognition; Dependency) and five stages, correlated with disease severity, patients’ quality of life and ...
Diego Santos-García, Lydia López-Manzanares, Inés Muro, Pablo Lorenzo-Barreto, Elena Casas Peña, Rocío García-Ramos, Tamara Fernández Valle, Carlos Morata-Martínez, Raquel Baviera-Muñoz, Irene Martínez-Torres, María Álvarez-Sauco, Déborah Alonso-Modino, Inés Legarda, María Fuensanta Valero-García, José Andrés Suárez-Muñoz, Juan Carlos Martínez-Castrillo, Ana Belén Perona, Jose María Salom, Esther Cubo, Caridad Valero-Merino, Nuria López-Ariztegui, Pilar Sánchez Alonso, Sabela Novo Ponte, Elisa Gamo Gónzález, Raquel Martín García, Raúl Espinosa, Mar Carmona, Cici Esmerali Feliz, Pedro García Ruíz, Teresa Muñoz Ruíz, Beatriz Fernández Rodríguez, Marina Mata Alvarez-Santullano   +31 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Advances in the Immunobiological Therapies for Advanced Melanoma

Actas Dermo-Sifiliográficas (English Edition), 2017
Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy ...
M C, Pérez Gago, O, Saavedra Santa Gadea, L, de la Cruz-Merino   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source