Results 141 to 150 of about 49,140 (359)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Inhibition of advanced glycation end products and protein oxidation by leaf extracts and phenolics from Chilean bean landraces

, 2022
Felipe Ávila, Nadia Cruz, Jazmín Alarcón‐Espósito, Nélida Nina, Hernán Paillan, Katherine Márquez, Denis Fuentealba, Alberto Burgos-Edwards, Cristina Theoduloz, Carmina Vejar-Vivar, Guillermo Schmeda‐Hirschmann   +10 more
openalex   +1 more source

Dietary advanced glycation end-products and postmenopausal hot flashes: A post-hoc analysis of a 12-week randomized clinical trial [PDF]

, 2023
Hana Kahleová, Tatiana Znayenko‐Miller, Jaime Uribarri, Natalie Schmidt, Sinjana Kolipaka, Ellen Hata, Danielle N. Holtz, Macy Sutton, Richard Holubkov, Neal D. Barnard   +9 more
openalex   +1 more source

Upcycling orange by‐product: phenolic bioaccessibility and technological features of jelly candies enriched with hydroalcoholic and enzymatic extracts

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Phenolic extracts are recognized for their health‐promoting properties, although some physicochemical characteristics limit their food applications. The present study aimed to valorize orange juice by‐products through enzymatic and hydroalcoholic extraction to obtain flavonoid ingredients and to evaluate their application in pectin ...
Bárbara Morandi Lepaus, Nathalia Almeida Costa, Gabriela de Matuoka e Chiocchetti, Paula de Paula Menezes Barbosa, Marise Bonifácio Queiroz, Izabela Dutra Alvim, Juliana Alves Macedo, Gabriela Alves Macedo   +7 more
wiley   +1 more source

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Szabó, András, Vér, Ágota, Zádor, Ernő   +3 more
core  

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

Advanced Glycation End-Product Precursor Methylglyoxal May Lead to Development of Alzheimer’s Disease

Diabetes, Metabolic Syndrome and Obesity, 2022
Wai Yin Li,1 Cheuk Yan Lee,1 Kwan Ming Lee,2 Ge Zhang,1,3 Aiping Lyu,1,3 Kevin Kin Man Yue1 1School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, People’s Republic of China; 2Department of Biology, Hong Kong Baptist University, Hong
Li WY, Lee CY, Lee KM, Zhang G, Lyu A, Yue KKM   +5 more
doaj  

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Frailty and aging are associated with cognitive decline and dermal advanced glycation end-product accumulation in older Japanese men

Archives of Gerontology and Geriatrics Plus
Background: Dermal advanced glycation end-product (AGE) accumulation is associated with various diseases, as well as frailty and aging. Frailty and aging are well known to be associated with a decline in cognitive function.
Satoko Takei, Masayuki Ochi, Akira Shiraoka, Sayaka Matsumoto, Saho Fujishita, Yoko Okada, Shiroh Miura, Hirofumi Ochi, Michiya Igase, Yasumasa Ohyagi   +9 more
doaj   +1 more source