Results 21 to 30 of about 37,721 (216)

Advanced glycation end-products: a review [PDF]

Diabetologia, 2001
Advanced glycation end-products are a complex and heterogeneous group of compounds that have been implicated in diabetes related complications. At present it is not known if they are the cause or the consequence of the complications observed. We discuss the chemistry of advanced glycated end-product formation and their patho-biochemistry particularly ...
Trevor A. Mori, Anne Barden, Ravindra Singh, Lawrence J. Beilin   +3 more
openaire   +3 more sources

The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

Molecules, 2020
Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and pentose) via Maillard reaction.
C. Shen, Cheng-Hsun Lu, Cheng-Han Wu, Ko-Jen Li, Y. Kuo, S. Hsieh, Chia-Li Yu   +6 more
semanticscholar   +1 more source

The receptor for advanced glycation end product (RAGE) pathway in COVID-19

Biomarkers, 2020
Introduction Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor.
Demet Yalçın Kehribar, M. Cihangiroğlu, E. Sehmen, B. Avcı, A. Çapraz, Ayşe Yıldırım Bilgin, C. Gunaydin, M. Ozgen   +7 more
semanticscholar   +1 more source

Advanced glycation end‐products and the kidney [PDF]

European Journal of Clinical Investigation, 2010
Eur J Clin Invest 2010; 40 (8): 742–755AbstractBackground Advanced glycation end‐products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids.
Gunter Wolf, Sybille Franke, Martin Busch, Christiane Rüster   +3 more
openaire   +3 more sources

A comparative study of sulphated polysaccharide effects on advanced glycation end-product uptake and scavenger receptor class A level in macrophages

Diabetes & vascular disease research, 2020
Advanced glycation end-products, especially toxic advanced glycation end-products derived from glyceraldehyde (advanced glycation end-product-2) and glycolaldehyde (advanced glycation end-product-3), are biologically reactive compounds associated with ...
T. Nishinaka, S. Mori, Y. Yamazaki, A. Niwa, H. Wake, T. Yoshino, M. Nishibori, Hideo Takahashi   +7 more
semanticscholar   +1 more source

Receptor of advanced glycation end product (RAGE) polymorphism and oxidative status in Hashimoto’s thyroiditis in Egyptian female patients: case control study

Egyptian Journal of Medical Human Genetics, 2022
Background Hashimoto's thyroiditis is the most widespread autoimmune illness targeting a specific organ. "Redox homeostasis" is achieved when the production of Reactive Oxygen Species and their elimination are in balance. Advanced glycation end products (
Noura Mostafa Mohamed, Azza H. Abd elfatah   +1 more
doaj   +1 more source

Glyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Oxidative Damage and Inflammatory Response by Interacting with RAGE

Antioxidants, 2021
The glyoxal-lysine dimer (GOLD), which is a glyoxal (GO)-derived advanced glycation end product (AGE), is produced by the glycation reaction. In this study, we evaluated the effect of GOLD on the oxidative damage and inflammatory response in SV40 MES 13 ...
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha   +6 more
doaj   +1 more source

Contribution of Glycation and Oxidative Stress to Thyroid Gland Pathology—A Pilot Study

Biomolecules, 2021
The patho-mechanism of changes in the thyroid gland, including carcinogenesis, is a complex process, which involves oxidative stress. The goal of our investigation was to verify the extent of stress in the thyroid gland related to glycation.
Aleksandra Kuzan, Emilia Królewicz, Karolina Nowakowska, Kamilla Stach, Krzysztof Kaliszewski, Paweł Domosławski, Łukasz Kotyra, Andrzej Gamian, Irena Kustrzeba-Wójcicka   +8 more
doaj   +1 more source

Advanced Glycation End Products in the Pathogenesis of Psoriasis [PDF]

International Journal of Molecular Sciences, 2017
Advanced glycation end products (AGEs) are extremely oxidant and biologically reactive compounds, which form through oxidation of sugars, lipids and amino acids to create aldehydes that bind covalently to proteins. AGEs formation and accumulation in human tissues is a physiological process during ageing but it is enhanced in case of persistent ...
Anastasia Papagrigoraki, Giampiero Girolomoni, Micol Del Giglio, Paolo Gisondi, Martina Maurelli   +4 more
openaire   +3 more sources

Association between plasma sRAGE and emphysema according to the genotypes of AGER gene

BMC Pulmonary Medicine, 2022
Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin, Myung-nam Lim, Jeeyoung Kim, So Hyeon Bak, Woo Jin Kim   +4 more
doaj   +1 more source