Results 41 to 50 of about 49,140 (359)

Advanced glycation end products and diabetic retinopathy [PDF]

Journal of Ocular Biology, Diseases, and Informatics, 2012
Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy.
Yashodhara, Sharma, Sandeep, Saxena, Arvind, Mishra, Anita, Saxena, Shankar Madhav, Natu   +4 more
openaire   +2 more sources

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]

, 2012
Peer reviewedPublisher ...
Berg, Daniela, Fleckenstein, Corinna, Itohara, Shigeyoshi, Lang, Johannes, Maetzler, Walter, Martin, Heather Louise, Mounsey, Ross Brian, Mustafa, Sarah, Sathe, Kinnari, Schulte, Claudia, Synofzik, Matthis, Teismann, Peter, Vukovic, Zvonimir   +12 more
core   +1 more source

Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability

Cellular Physiology and Biochemistry, 2018
Background/Aims: Disruption of endothelial barrier integrity in response to advanced glycation end products (AEGs) stimulation contributes to vasculopathy associated with diabetes mellitus. Mammalian diaphanous-related formin (mDia1) has been reported to
Xiaoyan Zhou, Jie Weng, Jing Xu, Qiulin Xu, Weiju Wang, Weijin Zhang, Qiaobing Huang, Xiaohua Guo   +7 more
doaj   +1 more source

Advanced Glycation End Products and Diabetic Complications [PDF]

The Korean Journal of Physiology & Pharmacology, 2014
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy ...
Singh, Varun Parkash, Bali, Anjana, Singh, Nirmal, Jaggi, Amteshwar Singh   +3 more
openaire   +2 more sources

Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells

Cells, 2020
Neuroblastoma is the second most frequent extracranial tumor, affecting young children worldwide. One hallmark of tumors such as neuroblastomas, is the expression of polysialic acid, which interferes with adhesion and may promote invasion and metastasis.
Maximilian Scheer, Kaya Bork, Frieder Simon, Manimozhi Nagasundaram, Rüdiger Horstkorte, Vinayaga Srinivasan Gnanapragassam   +5 more
doaj   +1 more source

O-GlcNAcylation is essential for therapeutic mitochondrial transplantation

Communications Medicine, 2023
Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular ...
Ji Hyun Park, Masayoshi Tanaka, Takafumi Nakano, Ester Licastro, Yoshihiko Nakamura, Wenlu Li, Elga Esposito, Emiri T. Mandeville, Sherry Hsiang-Yi Chou, MingMing Ning, Eng H. Lo, Kazuhide Hayakawa   +11 more
doaj   +1 more source

The role of RAGE, MAPK and NF-κB pathway in the advanced glycation end-products induced HUVECs dysfunction

Vascular Investigation and Therapy, 2022
OBJECTIVE: The objective of this study was to investigate how receptor for advanced glycation end-products–mitogen-activated protein kinase–nuclear factor-kappa B (MAPK-NF-κB) pathway is involved in advanced glycation end-product (AGE)-induced human ...
Xun Wang, Yi-Shu Wang, Qing-Long Zeng, Chen-Yang Qiu, Yang-Yan He, Zi-Heng Wu, Yun-Jun He, Tao Shang, Hong-Kun Zhang, Qian-Qian Zhu, Dong-Lin Li   +10 more
doaj   +1 more source

Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells. [PDF]

, 2011
The advanced glycation end products (AGEs) are associated with increased cardiac endothelial injury. However, no causative link has been established between increased AGEs and enhanced endothelial injury after ischemia/reperfusion.
Lau, Wayne B, Lian, Kun, Liu, Yi, Luan, Ronghua, Ma, Yanzhuo, Sun, Lu, Tao, Ling, Wang, Haichang, Wang, Rutao, Xia, Chenhai, Yang, Lu, Zhang, Rongqing   +11 more
core   +2 more sources

Lactobacillus fermentum as a new inhibitor to control advanced glycation end-product formation during vinegar fermentation

Food Science and Human Wellness, 2022
The inhibitory activity of lactic acid bacteria (LAB) toward advanced glycation end-products (AGEs) during vinegar fermentation was studied, and its relationships with the substrate consumption, antioxidant capacity, total phenolic content, total ...
Qin Li, Leibing Li, Hanjian Zhu, Fan Yang, Ke Xiao, Lin Zhang, Menglin Zhang, Yongsheng Peng, Chao Wang, Dongsheng Li, Qian Wu, Mengzhou Zhou   +11 more
doaj   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources