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Zinc against advanced glycation end products [PDF]
Clinical and Experimental Pharmacology and Physiology, 2018 SummaryAdvanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age‐related chronic diseases. Zinc has antioxidant, anti‐inflammatory and anti‐apoptotic potential. This study aimed to summarize effects of zinc onAGEformation andAGE‐induced damaging agents.
Sorayya Kheirouri +2 more
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Cells, 2019 Advanced glycation end products (AGEs) are the end products of the glycation reaction and have a great importance in clinical science for their association with oxidative stress and inflammation, which play a major role in most chronic diseases, such as ...
Margherita Borriello +2 more
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Chelating Activity of Advanced Glycation End-product Inhibitors*
Journal of Biological Chemistry, 2001 The advanced glycation end-product (AGE) hypothesis proposes that accelerated chemical modification of proteins by glucose during hyperglycemia contributes to the pathogenesis of diabetic complications.
David L. Price +3 more
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Majalah Obat Tradisional, 2021 Advanced Glycation End Products (AGE) are proteins that can cause cell destruction by increasing oxidative stress and inflammation. This product resulted from a series of chemical reactions after an initial glycation reaction. A Leydig cell is one of the
Dicky Moch Rizal +2 more
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Advanced Glycation End Products in Clinical Nephrology
Kidney and Blood Pressure Research, 2004 As a result of oxidative and carbonyl stress, advanced glycation end products (AGEs) are involved in the pathogenesis of severe and frequent diseases and their fatal vascular/cardiovascular complications, i.e. diabetes mellitus and its complications (nephropathy, angiopathy, neuropathy and retinopathy, renal failure and uremic and dialysis-associated ...
Vladimír Tesař +4 more
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Cellular Physiology and Biochemistry, 2015 Background/Aims: To investigate the effect of advanced glycation endproduct-induced autophagy in rat cardiomyocytes and to identify the role of autophagy in advanced glycation end product-induced cell apoptosis. Methods: After cultured rat cardiomyocytes
Pengfei Hu +6 more
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Disease Models & Mechanisms, 2018 Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge.
Divya Krishnamoorthy +6 more
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Advanced glycation end-products in diabetic nephropathy [PDF]
Nephrology Dialysis Transplantation, 1996 Advanced glycation end-products (AGEs) are the pigmented and fluorescent adduct formed by a non-enzymatic reaction between sugar and protein. Since AGEs are generated in high glucose milieu, then induce the structural and functional alteration of matnx proteins, and have biological effects on various kinds of cells including mesangial cells, AGEs have ...
Toshio Miyata +6 more
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Drug Design, Development and Therapy, 2020 Feng Gao,1 Shanyong Zhang2 1Department of Orthopedics, The Second Hospital of Jilin University, Changchun City, Jilin Province 130041, People’s Republic of China; 2Department of Spine Surgery, The Second Hospital of Jilin University, Changchun City,
Gao F, Zhang S
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Arthritis Research & Therapy, 2019 Background Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML).
Sabine Trellu +13 more
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