Results 101 to 110 of about 42,909 (288)

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies

Nutrition & Metabolism, 2018
Advanced glycation end products (AGEs), a group of compounds that are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of proteins, lipids or nucleic acids, can be obtained exogenously from diet or formed
Jie-Hua Chen, Xu Lin, Cuihong Bu, Xuguang Zhang   +3 more
doaj   +1 more source

Transcriptional regulation of endothelin-1 expression by advanced glycation end-products in human aortic endothelium is mediated via NF-kappaΒ and AP-1 [PDF]

, 2012
Advanced Glycation End-products (AGEs) are produced by the non-enzymatic glycation of proteins, lipids and nucleic acids, resulting in an overload of highly reactive molecules of endogenous or exogenous (dietary) origin.
Adamopoulos, Christos, Dalagiorgou, Georgia, Diamanti-Kandarakis, Evanthia, Gargalionis, Antonios N., Kandaraki, Eleni A., Papavassiliou, Athanasios G., Piperi, Christina   +6 more
core  

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]

, 2014
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo, Gallo, Juan Eduardo Maria, Ortiz, Gustavo Alfredo, Salica, Juan Pablo   +3 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Soluble receptor for advanced glycation end products in critically ill patients and its associations with other clinical markers and 28-day mortality

Clinical Interventions in Aging, 2014
Yanzi Cheng,1 Jiwen Zhong,1 Yang Xiang,1 Fan Zeng,1 Dehong Cai,2,† Ling Zhao11Department of Intensive Care Unit, Zhuhai People’s Hospital, Zhuhai, Guangdong, People’s Republic of China; 2Department of Endocrinology, Zhujiang Hospital ...
Cheng YZ, Zhong JW, Xiang Y, Zeng F, Cai DH, Zhao L   +5 more
doaj  

DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein? [PDF]

, 2017
The recently reported deglycating activity of DJ-1 reconciles several features previously described for the protein. The deglycating activity reported for DJ-1 may explain its different subcellular localizations, indeed the protein has been found in the ...
Bisaglia, Marco, DE LAZZARI, Federica
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Balancing the dual nature of glycotoxins: interplay of diet, digestion, and gut microbiome

Frontiers in Nutrition
Glycation chemistry, both in vitro and in vivo, is well-studied and known to result in a variety of products—from early glycation products, reactive carbonyl and oxygen species (RCS and ROS, respectively) to advanced glycation end products (AGEs ...
Halyna Semchyshyn
doaj   +1 more source