Results 121 to 130 of about 42,960 (301)

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs [PDF]

, 2019
The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases.
Dremin, Viktor V., Dunaev, Andrey V., Goltsov, Alexey, Makovik, Irina N., Rafailov, Edik U., Sokolovski, Sergei G., Zherebtsov, Evgeny A., Zherebtsova, Angelina I.   +7 more
core   +4 more sources

The intricacies of advanced glycation end products (AGEs) in diabetic neuropathy

3 Biotech
Advanced glycation end products (AGEs) are key molecular mediators implicated in diabetic neuropathy (DN), although their exact mechanisms and therapeutic implications remain unclear. This review systematically integrates current evidence on AGE formation, AGE-RAGE signaling, oxidative stress, and emerging interventions in DN.
Wajeeha Rao, Murtaza Hussain, Nida Naseem, Waseem Ahmad Siddiqui   +3 more
openaire   +3 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Age-Related Changes of Cystatin C Expression and Polarized Secretion by Retinal Pigment Epithelium: Potential Age-Related Macular Degeneration Links [PDF]

, 2014
PURPOSE: Cystatin C, a potent cysteine proteinase inhibitor, is abundantly secreted by the RPE and may contribute to regulating protein turnover in the Bruch's membrane (BrM).
Gray, Donna, Hiscott, Paul, Kay, Paul, Maminishkis, Arvydas, Paraoan, Luminita, Yang, Yit C   +5 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women [PDF]

Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well.
Basha, Walaa A., El-Bassyouni, Hala T., Kamal, Sanaa, Kholousi, Shams, Mohamed, Ramy, Reyad, Hanaa, Yousef, Walaa, Zaki, Moushira   +7 more
core   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source

The effect of advanced glycation endproduct accumulation on bone [PDF]

, 2017
Diabetes is associated with increased fracture risk, which leads to increased morbidity and eventual mortality with a substantial financial burden.
Van Vliet, Miranda
core   +1 more source

AGE-RAGE Axis Involvement in Allergies and Autoimmunity: Cellular Signaling, Barrier Dysfunction and Immune Polarization

Biomolecules
Advanced glycation end-products (AGEs) are a variety of endogenous and exogenous substances that play an important role in inflammation, allergies, and autoimmune diseases.
Enrica Dato, Alessandra Ventre, Marilena Di Salvo, Federica Nuccio, Marco Casciaro, Sebastiano Gangemi   +5 more
doaj   +1 more source