Results 111 to 120 of about 63,117 (342)

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Role of advanced glycation end products related to the onset of diabetic kidney disease complications

Clinical and Biomedical Research, 2017
Advanced glycation end products are known to play an important role in the diabetes complications, such as diabetic nephropathy. Most known pathways of diabetic complications involve oxidative stress, that have pivotal role in cell dysfunction onset and ...
Maria Luiza Almeida de Paula, Ana Marina Rodrigues Villela, Mauricio Massucati Negri, Salim Kanaan, Luciene de Carvalho Cardoso Weide   +4 more
doaj   +2 more sources

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Establishment and Application of a Method for the Systematic Evaluation, Screening, and Efficacy Verification of Various Cosmetic Ingredients Based on the Inhibition and Degradation of Advanced Glycation End Products

Cosmetics
Advanced glycation end products (AGEs) formed via glycation reactions negatively impact skin health by diminishing barrier function and elasticity and causing dullness. This study systematically evaluated the inhibitory and degradative capabilities of 24
Linlin Xu, Yuxin Song, Daichi Murata, Linxin Zheng, Guhui Chen, Junyong Song, Congfen He   +6 more
doaj   +1 more source

Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging.

Aging and Disease, 2014
Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and
Chandan Prasad, V. Imrhan, F. Marotta, S. Juma, P. Vijayagopal   +4 more
semanticscholar   +1 more source

Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]

, 2017
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan, Jazayeri, Hossein E., Rabiee, Mohammad, Rajab, Asodollah, Tahriri, Mohammadreza, Tayebi, Lobat, Yazdanpanah, Sara   +6 more
core   +3 more sources

Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents

ChemBioChem, EarlyView.
Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova, I. Raluca Sardaru, Franciszek P. Warguła, Jos H. Hermans, Hjalmar P. Permentier, Peter L. Horvatovich, Martin D. Witte   +6 more
wiley   +1 more source

The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP)

Periodontology 2000, EarlyView., 2023
Abstract In this descriptive analysis of the 21‐year follow‐up data from the SHIP‐START cohort and the 7‐year follow‐up data from the SHIP‐TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in
Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter   +4 more
wiley   +1 more source