Results 111 to 120 of about 42,909 (288)

Age-Related Changes of Cystatin C Expression and Polarized Secretion by Retinal Pigment Epithelium: Potential Age-Related Macular Degeneration Links [PDF]

, 2014
PURPOSE: Cystatin C, a potent cysteine proteinase inhibitor, is abundantly secreted by the RPE and may contribute to regulating protein turnover in the Bruch's membrane (BrM).
Gray, Donna, Hiscott, Paul, Kay, Paul, Maminishkis, Arvydas, Paraoan, Luminita, Yang, Yit C   +5 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

The effect of advanced glycation endproduct accumulation on bone [PDF]

, 2017
Diabetes is associated with increased fracture risk, which leads to increased morbidity and eventual mortality with a substantial financial burden.
Van Vliet, Miranda
core  

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
A. Ceriello, Ahmed, Ahmed, Bailey, Banerjee, Beisswenger, Bhattacharjee, C. W. Bodmer, D. Zehnder, Edens, Formoso, Grant, Havel, Jialal, Lambeth, Langer, Leeuwenburgh, M. V. Chittari, N. Rabbani, Ohira, P. J. Thornalley, Packard, Schleicher, Sk  l  n, Thornalley, Witztum   +25 more
core   +3 more sources

A Nutritional Paradigm to Impede Cataract Initiation: A Narrative Review of Emerging Perspective on Nutraceuticals

Future Postharvest and Food, EarlyView.
By lowering oxidative stress and lens protein aggregation, nutraceuticals enriched with antioxidants may reduce the development of senile cataracts, demonstrating their potential as supplemental, non‐pharmacological cataract preventive methods. ABSTRACT This review explores the emerging evidence to accommodate the developing requirement of non ...
Moubani Dutta, Sankhajyoti Saha, Agnihiya Bosu   +2 more
wiley   +1 more source

Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells. [PDF]

, 2011
The advanced glycation end products (AGEs) are associated with increased cardiac endothelial injury. However, no causative link has been established between increased AGEs and enhanced endothelial injury after ischemia/reperfusion.
Lau, Wayne B, Lian, Kun, Liu, Yi, Luan, Ronghua, Ma, Yanzhuo, Sun, Lu, Tao, Ling, Wang, Haichang, Wang, Rutao, Xia, Chenhai, Yang, Lu, Zhang, Rongqing   +11 more
core   +2 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets

Journal of Pharmacological Sciences, 2017
Advanced glycation end-products (AGEs) are produced by non-enzymatic glycation between protein and reducing sugar such as glucose. Although glyceraldehyde-derived AGEs (Glycer-AGEs), one of the AGEs subspecies, have been reported to be involved in the ...
Yuta Morioka, Kiyoshi Teshigawara, Yasuko Tomono, Dengli Wang, Yasuhisa Izushi, Hidenori Wake, Keyue Liu, Hideo Kohka Takahashi, Shuji Mori, Masahiro Nishibori   +9 more
doaj   +1 more source