Results 141 to 150 of about 63,117 (342)

Age-Related Changes of Cystatin C Expression and Polarized Secretion by Retinal Pigment Epithelium: Potential Age-Related Macular Degeneration Links [PDF]

, 2014
PURPOSE: Cystatin C, a potent cysteine proteinase inhibitor, is abundantly secreted by the RPE and may contribute to regulating protein turnover in the Bruch's membrane (BrM).
Gray, Donna, Hiscott, Paul, Kay, Paul, Maminishkis, Arvydas, Paraoan, Luminita, Yang, Yit C   +5 more
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Receptor for Advanced Glycation End Products and Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science, 2004
Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation.
Jeanne M. Frederick, Kimberly A. Howes, Alexander Marks, Wolfgang Baehr, Joshua L. Dunaief, Ann H. Milam, Yang Liu   +6 more
openaire   +3 more sources

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets

Journal of Pharmacological Sciences, 2017
Advanced glycation end-products (AGEs) are produced by non-enzymatic glycation between protein and reducing sugar such as glucose. Although glyceraldehyde-derived AGEs (Glycer-AGEs), one of the AGEs subspecies, have been reported to be involved in the ...
Yuta Morioka, Kiyoshi Teshigawara, Yasuko Tomono, Dengli Wang, Yasuhisa Izushi, Hidenori Wake, Keyue Liu, Hideo Kohka Takahashi, Shuji Mori, Masahiro Nishibori   +9 more
doaj   +1 more source

In Vitro Kinetic Studies of Formation of Antigenic Advanced Glycation End Products (AGEs)

Journal of Biological Chemistry, 1997
Nonenzymatic protein glycation (Maillard reaction) leads to heterogeneous, toxic, and antigenic advanced glycation end products (“AGEs”) and reactive precursors that have been implicated in the pathogenesis of diabetes, Alzheimer's disease, and normal ...
Ashley Booth, R. Khalifah, P. Todd, B. Hudson   +3 more
semanticscholar   +1 more source

Mechanistic targeting of advanced glycation end-products in age-related diseases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-derived advanced glycation end-products (AGEs), contributes to morbidity associated with aging, age-related diseases, and metabolic diseases. In this review, we summarize pathways leading to formation of AGEs, largely from sugars and glycolytic intermediates, and ...
Sheldon Rowan, Allen Taylor, Eloy Bejarano   +2 more
openaire   +3 more sources

AKTIVITAS ANTIGLIKASI EKSTRAK DAUN KENIKIR (Cosmos caudatus Kunth) DENGAN METODE SPEKTROFOTOMETRI UV-VIS: ANTI-GLICATION ACTIVITY OF KENIKIR (Cosmos caudatus Kunth) LEAF EXTRACT USING SPECTROPHOTOMETRY UV-VIS METHOD [PDF]

Kenikir merupakan jenis sayuran yang sering dikonsumsi mentah sebagai lalapan dan dimasak sebagai sayur. Senyawa flavonoid dan fenolik yang terdapat pada daun kenikir dapat digunakan sebagai antiglikasi.
Aisyah, Nurul, Lindawati, Novena Yety
core   +2 more sources

Effect of the Consumption of Lean Red Meat from Beef (Pirenaica Breed) Versus Lean White Meat (Chicken) on the Gut Microbiota: A Randomized Cross‐Over Study in Healthy Young Adults

Molecular Nutrition &Food Research, EarlyView.
A randomized crossover trial in healthy young adults (n = 16) compared the effects of lean red meat from beef (Pirenaica breed) and lean white meat from chicken on the gut microbiota composition and function. Both meat diets caused modest changes in microbial diversity and composition, suggesting comparable impacts when consumed as part of a habitual ...
Isabel Rueda‐De Torre, Julio Plaza‐Diaz, María L. Miguel‐Berges, Angel Gil, Laura Grasa, Luis Mariano Esteban, Sergio Sabroso‐Lasa, María M. Campo, Pilar Santolaria, Luis A. Moreno, Alba M. Santaliestra‐Pasías   +10 more
wiley   +1 more source

Impact of glycation and advanced glycation end products (AGEs) on macrophage activation

, 2020
Glycation is the non-enzymatic reaction that leads to the formation of advanced glycation end products (AGEs). Glycation and the accumulation of AGEs are known to occur during normal aging, but also in the progression of diseases such as diabetes. In diabetic wounds macrophages show dysfunction during wound healing processes.
openaire   +3 more sources