Results 21 to 30 of about 3,175,008 (304)

The Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases

open access: yesBiomedicines, 2022
Autophagy is a highly conserved dynamic process by which cells deliver their contents to lysosomes for degradation, thus ensuring cell homeostasis. In response to environmental stress, the induction of autophagy is crucial for cell survival.
Marianna Carinci   +8 more
doaj   +1 more source

SMOC can act as both an antagonist and an expander of BMP signaling

open access: yeseLife, 2017
The matricellular protein SMOC (Secreted Modular Calcium binding protein) is conserved phylogenetically from vertebrates to arthropods. We showed previously that SMOC inhibits bone morphogenetic protein (BMP) signaling downstream of its receptor via ...
J Terrig Thomas   +6 more
doaj   +1 more source

Evaluating psychological therapies services: A review of outcome measures and their utility [PDF]

open access: yes, 2004
We describe the use of a number of outcome measures that have been used over the past eight years to evaluate adult psychological therapies services in the Wakefield & Pontefract locality of the South West Yorkshire Mental Health NHS Trust.
Lucock, Mike   +3 more
core   +2 more sources

Advances in hemodialysis therapy

open access: yesFaculty Reviews, 2023
End-stage renal disease (ESRD) continues to be a disease process with a high rate of hospitalization and mortality. There has been little innovation in nephrology over the last few decades compared to revolutionary high-tech advancements in other areas like oncology and cardiovascular medicine.
Thajudeen, Bijin   +2 more
openaire   +2 more sources

Dance movement psychotherapy practice in the UK:findings from the Arts Therapies Survey 2011 [PDF]

open access: yes, 2014
Arts therapies practice in the UK, due to its complexity, is rarely adequately described and what constitutes main features of the professions often remains unclear.
Karkou, Vicky, Zubala, Ania
core   +1 more source

Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases

open access: yesBiomedicines, 2021
A decline in mitochondrial redox homeostasis has been associated with the development of a wide range of inflammatory-related diseases. Continue discoveries demonstrate that mitochondria are pivotal elements to trigger inflammation and stimulate innate ...
Simone Patergnani   +4 more
doaj   +1 more source

Advances in Antiviral Therapy.

open access: yesJournal of Investigative Dermatology, 1984
Recent developments have increased the options for treatment of viral infections. Vidarabine, an agent originally released for herpes simplex encephalitis, has more recently been shown to be of benefit in neonatal herpes simplex infection and in varicella-zoster infections in immunocompromised hosts.
openaire   +2 more sources

Strategy for the Generation of Engineered Bone Constructs Based on Umbilical Cord Mesenchymal Stromal Cells Expanded with Human Platelet Lysate

open access: yesStem Cells International, 2019
Umbilical cord mesenchymal stromal cells (UC-MSC) are promising candidates for cell therapy due to their potent multilineage differentiation, enhanced self-renewal capacity, and immediate availability for clinical use.
Ingrid Silva-Cote   +7 more
doaj   +1 more source

Transcriptomics-informed pharmacology identifies epigenetic and cell cycle regulators that enhance AAV production

open access: yesMolecular Therapy: Methods & Clinical Development
Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy. However, these vectors have limited availability due to manufacturing challenges with productivity and quality.
Joshua Tworig   +5 more
doaj   +1 more source

Recombinant AAV batch profiling by nanopore sequencing elucidates product-related DNA impurities and vector genome length distribution

open access: yesMolecular Therapy: Methods & Clinical Development
During production, recombinant adeno-associated virus (rAAV) capsids are equipped with heterogeneous genetic payloads including undesired DNA impurities as well as truncated vector genomes.
Florian Dunker-Seidler   +5 more
doaj   +1 more source

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